摘要
目的探讨血清白细胞介素-2受体(IL-2R)与慢性乙型肝炎(CHB)患者肝脏组织病理学之间的关系。方法选取2018年2月-2019年2月上海中医药大学附属普陀医院确诊的59例CHB患者作为研究对象,予以肝穿刺活检,根据肝脏炎症及纤维化程度分为轻度炎症(G1~G2)和重度炎症组(G3~G4);轻度纤维化(S0~S2)和重度纤维化组(S3~S4),并检测患者血清肝功能、血脂、IL-2、IL-6、IL-8及IL-10指标。正态分布的计量资料2组间比较采用独立样本t检验;非正态分布的计量资料2组间比较采用Wilcoxon非参数检验。计数资料组间比较采用χ~2检验。相关性检验采用Spearman相关分析。结果肝组织纤维化程度随肝组织炎症程度增加而加重(rs=0.538,P <0.001)。患者血清ALT、AST、GGT水平在重度炎症组明显高于轻度炎症组[95.00(45.00~169.25) U/L vs 51.00(29.00~88.00) U/L,Z=-2.625,P=0.009;54.50(34.75~84.50) U/L vs 38.00(30.00~49.00) U/L,Z=-2.014,P=0.044;91.00(56.72~192.25) U/L vs 44.00(24.00~100.00) U/L,Z=-2.400,P=0.016];血清HDL在重度纤维化组明显高于轻度纤维化组[0.97(0.32~1.08) mmol/L vs 1.23(0.36~1.38) mmol/L,Z=-1.300,P=0.008];血清IL-2R水平在重度炎症组及重度纤维化组中明显高于轻度炎症组及轻度纤维化组[704.00(418.00~1038.00) U/ml vs 436.00(335.00~555.00) U/ml,Z=-3.405,P=0.001;735.00(523.00~890.50) U/ml vs 447.00(351.50~624.50) U/ml,Z=-5.358,P=0.001]。结论肝脏炎症程度与纤维化程度呈正相关,而血清IL-2R随着肝脏炎症和纤维化严重程度加重而表达上升,表明IL-2R能在一定程度上反映肝脏炎症及纤维化严重程度。
Objective To investigate the association between serum interleukin(IL)and liver pathological changes in patients with chronic hepatitis B(CHB).Methods A total of 59 patients with CHB who were treated in Putuo District Central Hospital of Shanghai from February 2018 to February 2019 were enrolled as subjects,and liver biopsy was performed for all patients.According to the degree of liver inflammation,the patients were divided into mild inflammation(G1-G2)group and severe inflammation(G3-G4)group,and according to the degree of liver fibrosis,the patients were divided into mild fibrosis(S0-S2)group and severe fibrosis(S3-S4)group.Serum liver function parameters,blood lipids,interleukin-2(IL-2),interleukin-6(IL-6),interleukin-8(IL-8),and interleukin-10(IL-10)were measured for all patients.The independent samples t-test was used for comparison of normally distributed continuous data between two groups,and the Wilcoxon non-parametric test was used for comparison of non-normally distributed continuous data between two groups;the chi-square test was used for comparison of categorical data between groups.A Spearman correlation analysis was also performed.Results The degree of liver fibrosis increased with the increase in liver inflammation(r s=0.538,P<0.001).Compared with the mild inflammation group,the severe inflammation group had significantly higher serum levels of alanine aminotransferase[95.00(45.00-169.25)U/L vs 51.00(29.00-88.00)U/L,Z=-2.625,P=0.009],aspartate aminotransferase[54.50(34.75-84.50)U/L vs 38.00(30.00-49.00)U/L,Z=-2.014,P=0.044],and gamma-glutamyl transpeptidase[91.00(56.72-192.25)U/L vs 44.00(24.00-100.00)U/L,Z=-2.400,P=0.016].The severe fibrosis group had a significantly higher serum level of high-density lipoprotein than the mild fibrosis group[0.97(0.32-1.08)mmol/L vs 1.23(0.36-1.38)mmol/L,Z=-1.300,P=0.008].The severe inflammation group had a significantly higher serum level of IL-2 receptor than the mild inflammation group[704.00(418.00-1038.00)U/ml vs 436.00(335.00-555.00)U/ml,Z=-3.405,P=0.001],a
作者
汪涛
蒋元烨
王学伟
高静静
曹勤
WANG Tao;JIANG Yuanye;WANG Xuewei;GAO Jingjing;CAO Qin(Department of Gastroenterology,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第11期2441-2445,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金青年项目(81703879)
上海市卫计委临床研究专项面上项目(201840377,201940449)
普陀区科委自主创新项目(ptkwws201813)
上海市普陀区卫生系统自主创新科研资助项目(ptkwwws201806)。
