摘要
目的探讨新辅助化疗TAC方案联合改良根治手术治疗乳腺癌的临床观察及对Ki-67表达的影响。方法选择2016年1月—2017年12月本院收治的96例乳腺癌患者作为研究对象,采用随机数表法分为对照组和实验组两组,每组各48例。对照组采用改良根治手术治疗,实验组在改良根治手术前采用TAC化疗。观察患者手术情况、疗效、局部复发转移,术后并发症的发生以及Ki-67的增殖表达情况。结果实验组患者手术时间、术中出血量明显均少于对照组,差异有统计学意义(P<0.05);实验组患者的疗效总有效率显著优于对照组,差异有统计学意义(P<0.05);实验组患者的疾病控制率明显高于对照组,差异有统计学意义(P<0.05);实验组患者术后并发症总发生率显著低于对照组,差异有统计学意义(P<0.05);实验组患者的术后复发率低于对照组,差异有统计学意义(P<0.05);实验组患者肿瘤组织中的Ki-67指数高表达显著低于对照组,差异有统计学意义(P<0.05)。结论新辅助化疗后改良根治手术治疗乳腺癌效果好,肿瘤组织增殖指数较低,患者手术时间短、术中出血量少,术后局部复发率低、术后并发症较少,预后较好。
Objective To explore the clinical observation of neoadjuvant chemotherapy TAC regimen combined with modified radical surgery for the treatment of breast cancer and its influence on Ki-67.Methods From January 2016 to December 2017, a total of 96 patients suffered with breast cancer those admitted to our hospital were randomly selected and randomly divided into a control group and an experimental group, 48 cases in each group. The control group received modified radical surgery, and the experimental group received TAC chemotherapy before modified radical surgery. The surgical situation, efficacy, local recurrence and metastasis, and postoperative complications and proliferation index Ki-67 were observed.Results The operation time and intraoperative blood loss in the experimental group were significantly lower than those in the control groupand the difference was statistically significant(P<0.05). The treatment effect of the experimental group was significantly higher than that of the control group, and the difference was statistically significant(P<0.05). Disease control rate of the experimental group was significantly higher than that of the control group(P<0.05). The total incidence of postoperative complications in the experimental group was significantly lower than that in the control group(P<0.05), and the recurrence rate in the experimental group was lower than that in the control group(P<0.05). The high expression rate of Ki-67 in tumor tissue of the experimental group was significantly lower than that of the control group, and the difference was statistically significant(P<0.05).Conclusions The treatment of breast cancer with TAC chemotherapy before modified radical surgery could reduce the proliferation index of nucleus for tumor tissues, the operation time is short, the amount of intraoperative bleeding is less, the local recurrence rate is low, the postoperative complications are less, and the prognosis will be fine.
作者
岳喜成
王丹娜
YUE Xi-Cheng(Department of surgical Oncology,the first affiliated hospital of Bengbu Medical College,Bengbu,Anhui,233004,China)
出处
《齐齐哈尔医学院学报》
2020年第16期2003-2006,共4页
Journal of Qiqihar Medical University
基金
安徽高校自然科学研究项目重点项目(KJ2019A0367)。
关键词
乳腺癌
改良根治手术
新辅助化疗
TAC化疗
临床疗效
KI-67
Breast cancer
Modified radical surgery
Neoadjuvant chemotherapy
TAC chemotherapy
Clinical efficacy
Ki-67
