摘要
良性前列腺增生(benign prostatic hyperplasia,BPH)是中老年男性常见疾病,下尿路综合征等临床症状严重影响中老年男性生活质量。雄激素和雄激素受体(androgen receptor,AR)对前列腺的发育和生长是必要的,越来越多的研究表明,AR在BPH中发挥重要作用,在BPH组织中AR被雄激素激活,参与调控下游相关转录因子的表达,从而引起前列腺细胞的异常增殖。该文综述了androgen/AR信号通路以及雄激素和AR在BPH中的功能及可能的作用机制,介绍通路相关调节因子在调控BPH中的作用。
BPH(benign prostatic hyperplasia)is a common disease in elderly male,which leads to lower urinary tract syndrome and seriously affects the quality of life in elderly male.Androgen and AR(androgen receptor)are essential for the development and growth of prostate.Studies show that AR plays an important role in BPH.AR is activated by dihydrotestosterone,which is involved in regulating the expression of downstream transcription factors,thus causing abnormal proliferation of prostate cells.This paper reviews the function of androgen/AR signaling pathway,androgen and AR in BPH and their possible mechanisms,and introduces the role of pathway related regulatory factors in BPH regulation.
作者
刘念
刘向云
LIU Nian;LIU Xiangyun(Shanghai Key Laboratory of Development and Guarantee of Human Sports Ability,Shanghai University of Sport,Shanghai 200438,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2020年第9期1669-1675,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81772429)资助的课题。
关键词
良性前列腺增生
雄激素
雄激素受体
信号通路
benign prostatic hyperplasia
androgen
androgen receptor
signaling pathway
