摘要
<strong>Background: </strong>Benign Prostatic Hyperplasia (BPH) is a common condition which occurs as men get older. <strong>Aim:</strong> We aimed at investigating the reproductive hormone profile of men with BPH and the relationship of these hormones with age. <strong>Methods:</strong> Twenty-nine men of age > 40 years were screened for prostate symptoms. The prostate examination included digital rectal examination and measurement of serum prostate-specific antigen levels. Demographic and clinical characteristics of subjects were obtained using a structured questionnaire. The serum levels of Testosterone (Te), Luteinizing hormone (LH), Follicle stimulating hormone (FSH) and Prolactin (PRL) were measured using ELISA method. <strong>Results:</strong> Our study indicated that age and levels of prostate specific antigen (PSA), LH and FSH were significantly (p < 0.05) higher in men with BPH compared with healthy controls. In contrast, the control group indicated significantly (p < 0.05) higher Te level compared with the BPH group. In patients with BPH, age was significantly (p < 0.05) correlated with the hypothalamic-pituitary-testicular axis hormones (LH, FSH and PRL), but not with the sex hormone, and testosterone. Majority (62.1%) of the patients with BPH indicated they had poor libido, while none of them indicated regular sexual activity with their spouses. <strong>Conclusion:</strong> This study suggests that the rise in serum levels of the hypothalamic-pituitary-testicular axis hormones in BPH patients as demonstrated by the present findings may be age-related since testicular dysfunction in aging men is associated with the decrease in androgen production which may stimulate an increased production of gonadotropins by negative feedback.
<strong>Background: </strong>Benign Prostatic Hyperplasia (BPH) is a common condition which occurs as men get older. <strong>Aim:</strong> We aimed at investigating the reproductive hormone profile of men with BPH and the relationship of these hormones with age. <strong>Methods:</strong> Twenty-nine men of age > 40 years were screened for prostate symptoms. The prostate examination included digital rectal examination and measurement of serum prostate-specific antigen levels. Demographic and clinical characteristics of subjects were obtained using a structured questionnaire. The serum levels of Testosterone (Te), Luteinizing hormone (LH), Follicle stimulating hormone (FSH) and Prolactin (PRL) were measured using ELISA method. <strong>Results:</strong> Our study indicated that age and levels of prostate specific antigen (PSA), LH and FSH were significantly (p < 0.05) higher in men with BPH compared with healthy controls. In contrast, the control group indicated significantly (p < 0.05) higher Te level compared with the BPH group. In patients with BPH, age was significantly (p < 0.05) correlated with the hypothalamic-pituitary-testicular axis hormones (LH, FSH and PRL), but not with the sex hormone, and testosterone. Majority (62.1%) of the patients with BPH indicated they had poor libido, while none of them indicated regular sexual activity with their spouses. <strong>Conclusion:</strong> This study suggests that the rise in serum levels of the hypothalamic-pituitary-testicular axis hormones in BPH patients as demonstrated by the present findings may be age-related since testicular dysfunction in aging men is associated with the decrease in androgen production which may stimulate an increased production of gonadotropins by negative feedback.
作者
Babatunde Ishola Gabriel Adejumo
Omolei Lilian Williams
Efosa Bolaji Odigie
Ifeoma Gloria Unachukwu
Oladimeji Nasiru Abdulrahman
Uchechukwu Dimkpa
Simon Uzor
Oyarazi Margaret Adebowale
Ojo Moses Oke
Babatunde Ishola Gabriel Adejumo;Omolei Lilian Williams;Efosa Bolaji Odigie;Ifeoma Gloria Unachukwu;Oladimeji Nasiru Abdulrahman;Uchechukwu Dimkpa;Simon Uzor;Oyarazi Margaret Adebowale;Ojo Moses Oke(Department of Medical Laboratory Science, University of Benin, Benin City, Nigeria;Department of Medical Laboratory Science, College of Health Technology, Offa, Nigeria;Department of Human Physiology, Nnamdi Azikwe University, Nnewi Campus, Nnewi, Nigeria;Department of Applied Science, Faculty of Health and Applied Sciences, University of West of England, Bristol, UK;Department of Virology/Immunology, Federal School of Medical Laboratory Science, Jos, Nigeria;Department of Medical Laboratory Science, College of Health Technology, Akure, Nigeria)
出处
《Health》
2020年第9期1121-1131,共11页
健康（英文）
