摘要
目的探讨氨磺必利联合丙戊酸镁对慢性精神分裂症患者糖脂代谢、泌乳素水平的影响。方法选取我院2019年1月至2020年1月收治的60例慢性精神分裂症患者作为研究对象,将其随机分为观察组(30例,氨磺必利+丙戊酸镁)和对照组(30例,氨磺必利)。比较两组治疗前、后的糖脂代谢指标、泌乳素水平及症状评分。结果治疗后,对照组的TC、TG、LDL、空腹血糖及泌乳素水平均较治疗前明显降低(P<0.05);治疗前、后,观察组的TC、TG、HDL、LDL、空腹血糖及泌乳素水平比较,差异均无统计学意义(P>0.05)。治疗后,两组的各项PANSS评分及总分均降低,且观察组明显低于对照组(P<0.05)。结论氨磺必利联合丙戊酸镁治疗慢性精神分裂症的效果显著,可改善患者的临床症状,且可在一定程度上减轻氨磺必利对糖脂代谢及泌乳素水平的影响。
Objective To investigate the effect of amisulpride combined with magnesium valproate on glucose and lipid metabolism and prolactin level in patients with chronic schizophrenia.Methods A total of 60 patients with chronic schizophrenia admitted in our hospital from January 2019 to January 2020 were selected as the research objects and randomly divided into observation group(30 cases,amisulpride+magnesium valproate)and control group(30 cases,amisulpride).The glucose and lipid metabolism indexes,prolactin levels and symptom scores of the two groups before and after treatment were compared.Results After treatment,the levels of TC,TG,LDL,fasting blood glucose and prolactin in the control group were significantly lower than those before treatment(P<0.05);there were no significant differences in TC,TG,HDL,LDL,fasting blood glucose and prolactin levels in the observation group before and after treatment(P>0.05).After treatment,the PANSS scores and total score of the two groups decreased,and those in the observation group were significantly lower than the control group(P<0.05).Conclusion Amisulpride combined with magnesium valproate has a significant effect on chronic schizophrenia,which can improve the clinical symptoms of patients,and alleviate the effect of amisulpride on glucose and lipid metabolism and prolactin level to a certain extent.
作者
董爱国
赵丽丽
DONG Aiguo;ZHAO Lili(Psychiatry Department,the Affiliated Wuxi Mental Health Center of Nanjing Medical University,Wuxi 214000,China)
出处
《临床医学研究与实践》
2020年第32期61-62,65,共3页
Clinical Research and Practice
关键词
氨磺必利
丙戊酸镁
慢性精神分裂
糖脂代谢
泌乳素
amisulpride
magnesium valproate
chronic schizophrenia
glucose and lipid metabolism
prolactin
