摘要
肿瘤已成为危害人类健康和生命的第二大疾病,化学药物治疗(简称化疗)是最基本的治疗手段,但大多数化疗药物会对正常组织造成损害。如何更高效地递送抗肿瘤药物,提高药物在肿瘤部位的浓度,增强抗肿瘤作用,同时减少其在正常组织中的分布以减少对正常组织的损伤,是生物医药研究领域的难题。为实现抗肿瘤药物的精准递送并达到增效减毒的目标,研究人员利用指数富集的配体系统进化技术(SELEX技术)筛选可特异性靶向肿瘤标志物或肿瘤细胞的核酸适配体,设计了以适配体为靶向分子(配体)的新型脂质体靶向递药系统。笔者对核酸适配体技术与常见的肿瘤标志物进行了简要介绍,并对适配体-脂质体递药系统的抗肿瘤研究进展进行了总结与分析,可为选择适宜的肿瘤标志物作为靶标以及应用核酸适配体技术研发高效低毒的抗肿瘤中药脂质体靶向制剂提供参考,同时对于促进核酸适配体技术在靶向递药系统中的应用具有重要意义。
Tumor has become the second most serious disease that threatens human health and life.Treating with chemical drugs(referred to as chemotherapy) is the most basic treatment, but most chemotherapeutic drugs cause damage to normal tissues. It is a difficult problem in the field of biomedical research that how to deliver anti-tumor drugs more efficiently,increase the concentration of drugs in tumor tissues,enhance the anti-tumor effect,and decrease the drug distribution in normal tissues to weaken the damage to normal tissues. In order to achieve the goals of accurate delivery of anti-tumor drugs and synergism and attenuation,the researchers used systematic evolution of ligands by exponential enrichment technology(SELEX technology)to screen aptamers that can specifically target tumor markers or tumor cells,and designed the novel liposome targeting drug delivery system with aptamers as targeting molecules(ligands). This paper briefly introduced nucleic acid aptamer technology and common tumor markers,and reviewed the research advances on the antitumor effect of aptamer-liposome drug delivery system. It will provide references for the selection of appropriate tumor markers as targets and the application of aptamer technology in the research and development of high-efficiency and low-toxicity liposome targeting agents of anti-tumor traditional Chinese medicine.Meanwhile,it is of great significance for promoting the application of aptamer technology in targeted drug delivery systems.
作者
朱坤
杨中澜
张晓青
宁双成
周莉莉
邹蔓姝
夏新华
ZHU Kun;YANG Zhong-lan;ZHANG Xiao-qing;NING Shuang-cheng;ZHOU Li-li;ZOU Man-shu;XIA Xin-hua(Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第20期206-212,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(81573621)
湖南省研究生科研创新基金项目(CX20190574)
湖南省教育厅科学研究基金项目(19C1427)
湖南省自然科学基金项目(2019JJ50438)。
关键词
适配体-脂质体靶向递药系统
肿瘤标志物
核酸适配体技术
脂质体
抗肿瘤
指数富集的配体系统进化技术
aptamer-liposome targeted drug delivery system
tumor markers
nucleic acid aptamer technology
liposomes
anti-tumor
systematic evolution of ligands by exponential enrichment technology
