摘要
目的研究分析牙周基础治疗联合曲安奈德外用治疗牙龈扁平苔藓的临床效果。方法选择2019年1—9月于南京大学医学院附属口腔医院·南京市口腔医院就诊的牙龈扁平苔藓并伴有慢性牙周炎的患者40例,按随机数字表法分为治疗组和对照组,每组各20例。治疗组牙周基础治疗联合局部涂抹曲安奈德口腔软膏进行治疗,对照组局部涂抹曲安奈德口腔软膏进行治疗,两组均用药3个月。观察两组治疗前后疼痛程度、病损面积及总有效率。结果不同时间、分组患者疼痛程度不同,且时间、分组存在交互作用,差异有统计学意义(P<0.05)。进一步两两比较,组内比较:两组治疗后1周、2周、1个月、6个月疼痛程度低于治疗前,差异有统计学意义(P<0.05);组间比较:治疗后1周、2周,治疗组疼痛程度低于对照组,差异有统计学意义(P<0.05)。不同时间病损面积不同,差异有统计学意义(P<0.05),时间、分组存在交互作用,差异有统计学意义(P<0.05)。进一步两两比较,组内比较:两组治疗后1周、2周、1个月、6个月病损面积小于治疗前,差异有统计学意义(P<0.05);组间比较:治疗后2周、1个月和6个月治疗组病损面积小于对照组,差异有统计学意义(P<0.05)。治疗后1周、2周、1个月和6个月治疗组的总有效率高于对照组,差异有统计学意义(P<0.05)。结论牙周基础治疗联合曲安奈德口腔软膏治疗牙龈扁平苔藓短期见效快,维持效果好,长期疗效佳。
Objective To analyze the clinical effect of periodontal therapy combined with Triamcinolone Acetonide for treatment of lichen planus gingiva.Methods From January to September in 2019,40 patients affected with gingival lichen planus and chronic periodontitis diagnosed in the clinics of Nanjing Stomatological Hospital Medical School of Nanjing University,according to the random number table method,the patients were randomly divided into the treatment group and the control group,with 20 patients in each group.The treatment group was treated with periodontal therapy combined with topical triamcinolone acetonide oral ointment,while the control group was treated with topical triamcinolone acetonide oral ointment.Both groups were given the drug for three months,the pain degree,lesion area and total effective rate before and after treatment were observed.Results The pain degree of patients in different time and groups was different,and there was interaction between time and groups,and the differences were statistically significant(P<0.05).Further pair comparison and intra-group comparison:the pain degree of the two groups at one week,two weeks,one month and six months after treatment were lower than those before treatment,and the difference were statistically significant(P<0.05).Comparison between groups:one week and two weeks after treatment,the pain degree of the treatment group was lower than that of the control group,with statistically significant differences(P<0.05).The lesion area was different at different times,and the difference was statistically significants(P<0.05);there was interaction between time and groups,and the difference was statistically significant(P<0.05).Further pairwise comparison and intra-group comparison:the lesion area at one week,two weeks,one month and six months after treatment were smaller than that before treatment,and the differences were statistically significant(P<0.05).Two weeks,one month and six months after treatment,the lesion area of the treatment group were smaller than that of t
作者
王翔
张鹏
郑丽纯
王文梅
段宁
储志娟
WANG Xiang;ZHANG Peng;ZHENG Lichun;WANG Wenmei;DUAN Ning;CHU Zhijuan(Department of Oral Mucosal Diseases,Nanjing Stomatological HospitalMedical School of Nanjing University,Jiangsu Province,Nanjing210008,China;Department of Periodontal Disease Division,Nanjing Stomatological HospitalMedical School of Nanjing University,Jiangsu Province,Nanjing210008,China;Department of Preventive Stomatology,Nanjing Stomatological HospitalMedical School of Nanjing University,Jiangsu Province,Nanjing210008,China)
出处
《中国医药导报》
CAS
2020年第30期130-133,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81870767、81570978)
江苏省青年医学重点人才项目(QNRC2016118)
江苏省卫生计生委预防医学科研课题(Y2015004)
南京市卫生计生委医学科技发展项目(ZKX17033、YKK16162)。
关键词
口腔扁平苔藓
曲安奈德
牙周基础治疗
临床疗效
Oral lichen planus
Triamcinolone Acetonide
Initial periodontal treatment
Clinical effect
