摘要
目的研究渴络欣胶囊联合盐酸贝那普利片治疗糖尿病肾病的临床疗效。方法选取2018年3月—2020年3月郑州市金水区总医院收治的60例糖尿病肾病患者,将所有患者随机分为对照组和治疗组,每组各30例。对照组患者口服盐酸贝那普利片,10 mg/次,1次/d。治疗组在对照组基础上口服渴络欣胶囊,4粒/次,3次/d。两组患者持续治疗2个月。观察两组患者临床疗效,比较两组的24 h尿蛋白定量、尿素氮(BUN)、尿白蛋白排泄率(UAER)、血肌酐(Scr)、血清细胞因子水平。结果治疗后,对照组总有效率为76.67%,治疗组总有效率为93.33%,治疗组临床疗效明显较高(P<0.05)。治疗后,两组24 h尿蛋白定量、BUN、UAER、Scr水平显著降低(P<0.05);并且治疗组24 h尿蛋白定量、BUN、UAER、Scr水平降低较明显(P<0.05)。治疗后,两组血清同型半胱氨酸(Hcy)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平显著降低(P<0.05);且治疗组血清Hcy、TNF-α和IL-6水平降低较明显(P<0.05)。结论渴络欣胶囊联合盐酸贝那普利片治疗糖尿病肾病具有较好的疗效,可改善肾功能,降低血清炎性因子水平。
Objective To study the effect of Keluoxin Capsules combined with Benazepril Hydrochloride Tablets in treatment of diabetic nephropathy.Methods Patients(60 cases)with diabetic nephropathy in Jinshui District General Hospital of Zhengzhou from March 2018 to March 2020 were randomly divided into control and treatment groups,and each group had 30 cases.Patients in the control group were po administered with Benazepril Hydrochloride Tablets,10 mg/time,once daily.Patients in the treatment group were po administered with Keluoxin Capsules on the basis of the control group,4 grains/time,three times daily.Patients in two groups were treated for 2 months.After treatment,the clinical efficacies were evaluated,and the levels of 24 h urinary protein quantitation,BUN,UAER,Scr,and the serum cytokine levels in two groups were compared.Results After treatment,the total effective rate of the control group was 76.67%,and the total effective rate of the treatment group was 93.33%,and the clinical efficacy of the treatment group was significantly higher than that of the control group(P<0.05).After treatment,the levels of 24 h urinary protein quantitation,BUN,UAER,and Scr in two groups were significantly decreased(P<0.05),and the levels of 24 h urinary protein quantitation,BUN,UAER,and Scr in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the serum levels of Hcy,TNF-α,and IL-6 in two groups were significantly decreased(P<0.05),and the serum levels of Hcy,TNF-α,and IL-6 in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Keluoxin Capsules combined with Benazepril Hydrochloride Tablets has clinical curative effect in treatment of diabetic nephropathy,can improve renal function,and reduce the serum level of inflammatory factors.
作者
陈珊珊
程慧茹
闫寒冰
刘笑笑
CHEN Shan-shan;CHENG Hui-ru;YAN Han-bing;LIU Xiao-xiao(No.2 Department of Internal Medicine,Jinshui District General Hospital of Zhengzhou,Zhengzhou 450000,China)
出处
《现代药物与临床》
CAS
2020年第9期1763-1766,共4页
Drugs & Clinic
基金
河南省医学科技攻关计划省部共建项目(SB201901075)。
关键词
渴络欣胶囊
盐酸贝那普利片
糖尿病肾病
肾功能指标
24
h尿蛋白定量
炎性因子
Keluoxin Capsules
Benazepril Hydrochloride Tablets
diabetic nephropathy
renal function index
24 h urinary protein quantitation
inflammatory factor
