摘要
目的研究前列地尔注射剂对慢性肾功能不全进行治疗的临床效果。方法本文研究对象为2019年3月至2020年1月到我院治疗的慢性肾功能不全者,其中经常规用药方案治疗者29例,为对照组,经常规基础治疗联合前列地尔注射剂治疗者29例,为观察组。比较两组患者经过不同治疗以后的不良反应发生率、24 h尿蛋白水平、血尿酸水平、血尿素氮水平、血肌酐水平、尿量、生活质量、生命尊严和满意度等。结果①观察组(5例,占17.24%)治疗后的用药不良反应发生率和对照组(4例,占13.79%)相比差异不显著(P>0.05)。②治疗前,两组患者的24 h尿蛋白水平、血尿酸水平、血尿素氮水平、血肌酐水平差异不显著(P>0.05),治疗后,观察组的24 h尿蛋白水平、血尿酸水平、血尿素氮水平、血肌酐水平更好,差异有统计学意义(P<0.05)。③治疗前,两组患者的SF-36评分差异不明显(P>0.05),治疗后,观察组的SF-36评分改善程度更好,差异有统计学意义(P<0.05)。④治疗前,两组患者的PDI评分差异不显著(P>0.05),治疗后,观察组的PDI评分改善程度优于对照组,差异有统计学意义(P<0.05)。⑤观察组28例患者满意,占96.55%,相比对照组的23例满意占79.31%更为可靠,差异有统计学意义(P<0.05)。结论针对慢性肾功能不全的患者,在常规用药的基础上使用前列地尔注射液的用药安全性较高,能够改善患者的肾功能指标,提升患者的生活质量和生命尊严,使患者的满意度大大提升是值得推荐的一种理想的治疗方法。
Objective To study the clinical effect of alprostadil injection in the treatment of chronic renal insufficiency.Methods The subjects of this study were patients with chronic renal insufficiency who were treated in our hospital from March 2019 to January 2020.Among them,29 patients were treated with conventional drug regimens,which were the control group,and 29 patients were treated with conventional basic therapy combined with alprostadil injection,which Nere the observation group.The incidence of side effects,24-hour urine protein level,blood uric acid level,and blood urea nitrogen level,serum creatinine level,urine output,quality of life,life dignity and satisfaction,etc were compared between the two groups after different treatments.Results(1)There was no significant difference in the incidence of adverse drug reactions between the observation group and the control group after treatment(P>0.05).(2)Before treatment,there was no significant difference in 24-hour urine protein level,blood uric acid level,blood urea nitrogen level,and serum creatinine level between the two groups(P>0.05).Aftrer treatment,the 24-hour urine protein level,blood wric acid level,the blood urea nitrogen level and serum creatinine level in the observation group were better than the control group,and the difference was statistically significant(P<0.05).(3)Before treatment,there was no significant difference in the SF-36 score between the two groups(P>0.05).After treatment,the SF-36 score in the observation group improved better,and the difference was statistically significant(P<0.05).(4)Before treatment,there was no significant difference in PDI score between the two groups(P>0.05).After treatment,the improvement of PDI score in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).(5)The 28 patients in the observation group were satisfied,accounting for 96.55%,which was more reliable than the 23 patients in the control group,which accounted for 79.31%,and the difference w
作者
刘向东
LIU Xiangdong(The Second People's Hospital of Liaoyang,Liaoyang 111000,China)
出处
《中国医药指南》
2022年第18期21-24,共4页
Guide of China Medicine
关键词
前列地尔注射剂
慢性肾功能不全
不良反应
生活质量
生命尊严
满意度
Alprostadil injection
Chronic renal insufficiency
Side effects
Quality of life
Dignity of life
Satisfaction
