摘要
目的分析地屈孕酮与黄体酮治疗黄体功能不全型先兆流产的应用价值。方法50例黄体功能不全型先兆流产患者,随机平行分为对照组与研究组,各25例。对照组给予黄体酮治疗,研究组经予地屈孕酮治疗。对比两组腹部疼痛缓解时间、腰酸缓解时间、恢复正常活动时间、孕酮水平、保胎成功率、不良反应(头痛、皮肤红肿)发生率。结果研究组腹部疼痛缓解时间(3.21±1.11)d、腰酸缓解时间(3.22±1.45)d、恢复正常活动时间(3.76±1.56)d均短于对照组的(5.43±1.09)、(5.67±1.13)、(5.79±1.44)d,差异均具有统计学意义(P<0.05);两组的孕酮水平对比,差异无统计学意义(P>0.05)。研究组不良反应发生率8.00%(2/25)低于对照组的32.00%(8/25),保胎成功率96.00%(24/25)高于对照组的76.00%(19/25),差异均具有统计学意义(P<0.05)。结论地屈孕酮与黄体酮治疗黄体功能不全型先兆流产患者,均可以有效提高孕酮水平,但应用地屈孕酮后的不良反应少、临床症状缓解时间短,且保胎率更高。
Objective To analyze the practical value of dydrogesterone and progesterone in the treatment of threatened abortion due to luteal insufficiency.Methods A total of 50 patients with threatened abortion due to luteal insufficienc were randomly divided into control group and research group,with 25 cases in each group.The control group was treated with progesterone,and the research group was treated with dydrogesterone.The abdominal pain relief time,lumbar acid relief time,recovery time to normal activities,progesterone level,success rate of pregnancy,incidence of adverse reactions(headache,skin redness)were compared between the two groups.Results The abdominal pain relief time(3.21±1.11)d,lumbar acid relief time(3.22±1.45)d and recovery time to normal activities(3.76±1.56)d of the research group were shorter than(5.43±1.09),(5.67±1.13)and(5.79±1.44)d of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in progesterone level between the two groups(P>0.05).The incidence of adverse reactions 8.00%(2/25)of the research group was lower than 32.00%(8/25)of the control group,and success rate of pregnancy 96.00%(24/25)was higher than 76.00%(19/25)of the control group,and the difference was statistically significant(P<0.05).Conclusion Both dydrogesterone and progesterone can effectively improve progesterone level in the treatment of patients with threatened abortion due to luteal insufficiency.However,dydrogesterone shows less adverse reactions,shorter clinical symptoms remission time and higher success rate of pregnancy than progesterone.
作者
崔磊
CUI Lei(Department of Obstetrics and Gynecology,Shenyang Deji Hospital,Shenyang 110000,China)
出处
《中国实用医药》
2020年第28期114-116,共3页
China Practical Medicine
关键词
地屈孕酮
黄体酮
黄体功能不全
先兆流产
Dydrogesterone
Progesterone
Luteal insufficiency
Threatened abortion
