摘要
目的通过检测女性不孕症患者性激素水平,分析其变化规律,为女性不孕症病因诊断提供依据。方法选取2015年3月~2017年5月南京金陵中西医结合医院(以下简称"我院")部分女性不孕症患者130例作为研究组,根据月经情况,将其分为月经正常组(50例)和月经紊乱组(80例),选择同期于我院体检的50名已育健康妇女作为对照组。所有受试者均采用化学发光免疫法测定血清促卵泡激素(FSH)、促黄体生成素(LH)、雌二醇(E_2)、垂体泌乳素(PRL)、睾酮及黄体酮水平。结果月经紊乱组FSH、LH、PRL及睾酮水平均高于对照组及月经正常组(P <0.05或P <0.01);E_2水平明显低于对照组及月经正常组(P <0.01);黄体酮水平差异无统计学意义(P>0.05)。而月经正常组6项激素水平与对照组差异无统计学意义(P> 0.05)。月经紊乱组不同病因不孕患者性激素水平与对照组及月经正常组比较:49例多囊卵巢综合征患者中,LH、睾酮及PRL均明显升高(P <0.05或P <0.01),并且LH/FSH≥2;21例高泌乳血症患者中,PRL显著升高(P <0.01)、而E_2明显降低(P <0.05);5例早发性卵巢功能不全患者中,FSH、LH显著升高(P <0.01)、而E_2显著降低(P <0.01);5例甲状腺功能减退患者中,E_2、睾酮明显降低(P <0.05),而FSH、LH及PRL明显升高(P <0.05或P <0.01)。结论月经紊乱组性激素水平异常,提示内分泌因素是不孕的原因。不同病因不孕症所表现的各自不同的性激素异常,为不孕症病因分析提供了重要依据。
Objective To analyze the changes of sex hormones in female infertility patients,provide evidence for etiological diagnosis of female infertility.Methods From March 2015 to May 2017,130 cases of female infertility in Nanjing Jinling Hospital on Integeration of Chinese and Western Medicine("our hospital"for short)were selected as study group.According to the menstrual condition,it was divided into normal menstrual group(50 cases)and menstrual disorder group(80 cases).Fifty healthy women carried physical examination in our hospital at the same periods were selected as control group.Levels of serum follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),pituitary prolactin(PRL),testosterone and progesterone were measured by chemiluminescent Immunoassay.Results In the menstrual disorder group,serum FSH,LH,PRL and testosterone levels were higher than control group and menstrual normal group(P<0.05 or P<0.01).Level of serum E2 was significantly lower than that of control group and normal menstrual group(P<0.01).There was no significant difference between the six hormone levels and the control group in the normal menstrual group(P>0.05).The levels of sex hormones in patients with different causes of infertility were compared with those in control group and normal menstrual group:LH,testosterone and PRL in 49 patients with polycystic ovary syndrome significantly increased(P<0.05 or P<0.01),and LH/FSH≥2.In 21 patients with hyperlactation,PRL significantly increased(P<0.01),while E2 significantly decreased(P<0.05).In 5 patients with premature ovarian insufficiency,FSH and LH increased significantly(P<0.01),while E2 significantly decreased(P<0.01).In 5 hypothyroidism patients,E2 and testosterone decreased significantly(P<0.05),while FSH,LH and PRL increased significantly(P<0.05 or P<0.01).Conclusion The abnormal level of sex hormones in menstrual disorder group suggested that endocrine factors are the cause of infertility.The abnormal sex hormones in infertility of different etiologies provides an important
作者
王冲
孙瑞
吴周亚
WANG Chong;SUN Rui;WU Zhouya(Department of Nuclear Medicine,Nanjiang Hospital,Nanjing Medical University,Nanjing First Hospital,Jiangsu Province,Nanjing 210019,China;Department of Gynaecology,Nanjing Jinling Hospital on Integeration of Chinese and Western Medicine,Jiangsu Province,Nanjing 210029,China)
出处
《中国医药导报》
CAS
2018年第30期91-94,共4页
China Medical Herald
关键词
性激素
女性不孕
月经紊乱
化学发光免疫测定
Sex hormone
Female infertility
Menstrual disorder
Chemiluminescent immunoassay
