摘要
目的:探讨氯吡格雷联合丹参酮ⅡA磺酸钠注射液治疗冠心病心绞痛的疗效及其对血管内皮功能和微炎性反应状态的影响。方法:选取2015年6月至2019年6月浙江省磐安县人民医院收治的冠心病心绞痛患者100例,按治疗方法的不同分为试验组和对照组,每组50例,两组均给予常规对症治疗,对照组在常规治疗基础上联合氯吡格雷75 mg/次,1次/d,阿司匹林肠溶片150 mg/次,1次/d,试验组在常规治疗基础上给予氯吡格雷75 mg/次,1次/d,联合丹参酮ⅡA磺酸钠注射液60 mg加入5%葡萄糖溶液配制250 ml静脉滴注,每天1次。治疗4周为1个疗程。比较两组治疗后心绞痛发作次数、持续时间和疗效,同时检测两组治疗前后血管内皮相关细胞因子和外周血CD 4^+Foxp3^+Treg细胞表达率的改善水平,并进行比较。结果:两组治疗前心绞痛发作次数和持续时间比较差异无统计学意义(P>0.05);治疗后两组患者心绞痛发作次数和持续时间均较治疗前显著减少,且试验组治疗后心绞痛发作次数和持续时间均低于对照组[(0.4±0.1)次/d比(0.6±0.2)次/d、(3.4±1.2)min/次比(5.8±1.2)min/次],差异有统计学意义(P<0.05)。两组治疗后总有效率比较差异无统计学意义[98.0%(49/50)比92.0%(46/50)](P>0.05)。治疗前两组患者血浆一氧化氮(NO)、内皮素(ET)、血栓调节蛋白(TM)含量和CD4^+Foxp3^+Treg细胞阳性表达率比较差异无统计学意义(P>0.05);治疗后,两组NO、TM水平均较治疗前显著增加,ET、CD4^+Foxp3^+Treg细胞阳性表达率显著下降,差异有统计学意义(P<0.05);试验组治疗后血浆NO、TM含量均高于对照组[(82.5±5.1)ng/L比(71.9±4.)ng/L、(32.4±3.6)μmol/L比(25.2±3.6)μmol/L],ET、CD 4^+Foxp3^+Treg细胞阳性表达率低于对照组[(39.4±5.2)μmol/L比(46.7±5.4)μmol/L、(9.4±1.8)%比(10.6±1.7)%],差异有统计学意义(P<0.05)。结论:丹参酮ⅡA磺酸钠注射液联合氯吡格雷治疗冠心病心绞痛有助于提高心�
Objective To analyze the mid-term efficacy of sodium tanshinoneⅡA sulfonate injection combined with clopidogrel in the treatment of angina pectoris and its effect on vascular endothelial function and micro-inflammatory state.Methods One hundred patients with coronary heart disease and angina pectoris admitted to Pan′an County People′s Hospital from June 2015 to June 2019 were divided into two groups according treatment methods,with 50 patients in each group.On the basis of conventional symptomatic treatment,test group was given clopidogrel(75 mg once a day)combined with sodium tanshinoneⅡA sulfonate injection.In control group,clopidogrel(75 mg once a day)and aspirin(150 mg once a day)were given.One cycle was four weeks.The expression levels of vascular endothelial-associated cytokines and peripheral blood CD4^+Foxp3^+Treg cells were detected and compared between the two groups.Results The frequency and duration of angina pectoris before treatment in two groups had no significant differences(P>0.05);after treatment,the frequency and duration of angina pectoris significantly decreased in the two groups(P<0.05),the levels of frequency and duration of angina pectoris in test group were lower than those in control group[(0.4±0.1)times/d vs.(0.6±0.2)times/d,(3.4±1.2)times/d vs.(5.8±1.2)times/d,and there were significant differences(P<0.05).The total effective rate in two groups had no statistical significance[98.0%(49/50)vs.92.0%(46/50)](P>0.05).Before treatment,the levels of nitric oxide(NO),endothelin(ET),thrombomodulin(TM)and CD4^+Foxp3^+Treg in two groups had no significant differences(P>0.05).After treatment,the levels of NO,TM in two groups increased and the levels of ET,CD4^+Foxp3^+Treg in two groups decreased,and there were significant differences(P<0.05).The levels of NO,TM in test group were higher than those in control group[(82.5±5.1)ng/L vs.(71.9±4.)ng/L,(32.4±3.6)μmol/L vs.(25.2±3.6)μmol/L],the levels of ET,CD4^+Foxp3^+Treg in test group were lower than those in control group[(39.4±5.2)
作者
杨菊妹
孔松泉
Yang Jumei;Kong Songquan(Department of TCM Pharmacy,Pan′an County People′s Hospital,Zheiiang Pan′an 322300,China;Department of Rehabilitation,Pan′an County People′s Hospital,Zheiiang Pan′an 322300,China)
出处
《中国医师进修杂志》
2020年第10期944-948,共5页
Chinese Journal of Postgraduates of Medicine
关键词
心绞痛
疗效
丹参酮Ⅱ
A磺酸钠注射液
氯吡格雷
血管内皮功能
Angina pectoris
Efficacy
Sodium tanshinoneⅡA sulfonate injection
Clopidogrel
Vascular endothelial function
