摘要
目的探究胱抑素C(Cys C)和肾积液CT值在尿路结石梗阻性肾积脓患者中的临床意义。方法选取本院尿路结石梗阻性肾积液患者138例,其中肾积脓患者87例作为研究组,肾积水患者51例作为对照组。统计比较两组一般资料,检测对比两组肾功能指标[血液尿素氮(BUN)、肌酐(Cr)]、血清Cys C水平、肾积液CT值,分析血清Cys C水平与肾积液CT值相关性及两者与肾功能指标的关系,探究血清Cys C、肾积液CT值对尿路结石梗阻性肾积脓与肾积水的鉴别诊断价值。结果研究组血清BUN、Cr水平高于对照组(P<0.05);研究组血清Cys C水平、肾积液CT值高于对照组(P<0.05);血清Cys C水平与肾积液CT值呈正相关(P<0.05);血清Cys C水平、肾积液CT值与血清BUN、Cr水平呈正相关(P<0.05);血清Cys C水平、肾积液CT值联合鉴别诊断尿路结石梗阻性肾积脓与肾积水的曲线下面积(AUC)为0.841,大于二者单一诊断鉴别,联合诊断最佳诊断敏感度为68.63%,特异度为86.21%。结论尿路结石梗阻性肾积脓患者的血清Cys C表达水平及肾积液CT值异常升高,且与患者肾功能呈正相关关系,可辅助临床鉴别诊断尿路结石梗阻性肾积脓与肾积水,指导临床评估患者肾功能、制定针对性治疗方案。
Objective To explore the clinical significance of Cystatin C(Cys C)and CT value of renal effusion in patients with obstructive empyema of urinary tract stones.Methods A total of 138 patients with obstructive hydronephrosis of urinary tract stones in our hospital were selected,including 87 patients with renal empyema as the study group and 51 patients with hydronephrosis as the control group.The general data of the two groups were statistically compared.The renal function indexes[blood urea nitrogen(BUN),creatinine(CR)],serum Cys C and CT value of renal effusion of the two groups were detected and compared.The correlation between serum Cys C and CT value of renal effusion and the relationship between the two and renal function indexes was analyzed,and the diagnostic value was analyzed,and the diagnostic value of serum Cys C and CT value of hydronephrosis on urinary tract stone obstructive empyema and hydronephrosis was explored.Results The serum BUN and Cr levels of the research group were higher than those of the control group(P<0.05);the CT values of the serum Cys C and renal effusion in the research group were higher than those in the control group(P<0.05).Serum Cys C was positively correlated with CT value of renal effusion(P<0.05);serum Cys C and CT value of renal effusion were positively correlated with serum BUN and Cr levels(P<0.05).The area under the curve(AUC)of the combined diagnosis of serum Cys C and CT value of renal effusion combined with the differential diagnosis of urinary tract stone obstructive empyema and hydronephrosis was 0.841,which was greater than the single diagnosis of the two,the best diagnostic sensitivity of combined diagnosis was 68.63%and specificity was 86.21%.Conclusion Serum Cys C level and CT value of hydronephrosis in patients with urinary tract stone obstructive empyema are abnormally increased,and are positively correlated with the patients renal function,which can assist in the clinical differential diagnosis of urinary tract stone obstructive empyema and hydronephrosis,gui
作者
郭亮
徐鹏程
胡恒龙
GUO Liang;XU Pengcheng;HU Henglong(Department of Urology,Lu'an Hospital,Anhui Medical University,Liuan,Anhui,China,237000;Department of Urology,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,Hubei,China,430000)
出处
《分子诊断与治疗杂志》
2020年第10期1406-1410,共5页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金会(81800626)。
关键词
尿路结石梗阻性肾积脓
胱抑素C
肾积液CT值
Urinary tract stone obstructive empyema
Cystatin C
Renal effusion CT value
