摘要
目的:初步观察评估Mohs手术和光动力疗法(Photodynamic therapy,PDT)单独或联合治疗乳房外Paget病的临床疗效。方法:14例乳房外Paget病患者,根据治疗方式不同分为A组(单纯PDT治疗)、B组(PDT联合传统手术)、C组(Mohs手术)、D组(PDT联合Mohs手术)。观察四组疗效并随访2~14年。结果:A组患者症状改善,病灶残余10.02%;B、C、D三组患者症状消失,皮损消失,但B组经组织病理学证实有残留Paget细胞。C组切除面积大于D组。A、B、C三组均有1例复发,而D组无复发。结论:PDT联合Mohs手术治疗乳房外Paget病,能缩小切除面积,提高治愈率,减少复发,值得临床推荐。
Objective To evaluate the efficacy of photodynamic therapy(PDT)and Mohssurgery alone or combined in the treatment of extra-mammary Paget's disease(EMPD).Methods A total of 14 cases of diagnosed with extramammary Paget's disease were divided by different treatments intogroup A(PDT,3 cases),group B(the combination of PDT and traditional surgery,2 cases),group C(Mohs surgery,6 cases)and group D(the combination of PDT and Mohs surgery,3 cases).The clinical curative effect of the four groups was observed.All the patients were followed up for 2-14 years.Results Symptoms in group A were improved with residual lesions of 10.02%.Symptoms in B,C,and D groups disappeared,and skin lesions disappeared.However,there were Paget cells remained in group B.The resection area in group C was larger than that in group D.In the follow-up,the relapse occurred in the group A,B and C,but group D without relapse.Conclusion Photodynamic therapy combined with Mohs surgery treat patients withEMPD has the advantages of thorough treatment,little trauma,is worthy of clinical application.
作者
王奕
胡利萍
廖程琦
兰长贵
WANG Yi;HU Li-ping;LIAO Cheng-qi;LAN Chang-gui(Department of Medical Aesthetics,the Third People's Hospital of Chengdu,Chengdu 610000,Sichuan,China;Department of Dermatology,China National Nuclear Corporation(CNNC)416 Hospital,Chengdu 610051,Sichuan,China)
出处
《中国美容医学》
CAS
2020年第10期61-64,共4页
Chinese Journal of Aesthetic Medicine
