摘要
目的探究经皮冠状动脉介入术手术前后检测血清胱抑素C与对比剂肾病的临床意义。方法 2018年6月—2019年4月选取该院收治的经皮冠状动脉介入术治疗的冠心病患者76例,全部患者在手术前与手术后24 h晨起抽取静脉血5 mL,利用免疫比浊法对血清胱抑素C水平进行检测。分析患者术前与术后24 h血清胱抑素C与血清肌酐水平的变化、对比剂肾病的发生率、灵敏度与特异度。结果术后24 h血清胱抑素C与血清肌酐水平均高于术前,差异有统计学意义(t=7.423,P<0.001;t=2.793,P=0.006);以血清肌酐变化为标准,术后24 h对比剂肾病发生率7.89%;以血清胱抑素C升高基线水平的25%为标准,术后24 h对比剂肾病发生率19.74%,差异有统计学意义(χ^2=4.476,P=0.034);按照欧洲泌尿生殖放射协会(2005年)对比剂指南标准评定:血清胱抑素C诊断对比剂肾病的灵敏度93.75%,特异度90.00%。结论经皮冠状动脉介入术手术前后检测血清胱抑素C,具有较高的诊断灵敏度与特异度,可为对比剂肾病的预防与治疗提供有利条件。
Objective To explore the clinical significance of serum cystatin C and contrast medium nephropathy before and after percutaneous coronary intervention. Methods During the period from June 2018 to April 2019, 76 patients with coronary heart disease treated by percutaneous coronary intervention in the hospital were selected. All patients were drawn with 5 mL of venous blood before and 24 h after the operation, use immunoturbidimetric method to detect serum cystatin C level. The changes of serum cystatin C and serum creatinine levels before and 24 h after operation,the incidence, sensitivity, and specificity of contrast media nephropathy were analyzed. Results The levels of serum cystatin C and serum creatinine at 24 h after operation were higher than those before operation, the difference was statistically significant(t=7.423, P<0.001;t=2.793, P=0.006);the change of serum creatinine was used as the standard,and the contrast agent was used for 24 h after operation. The incidence of nephropathy was 7.89%;taking 25% of the baseline level of serum cystatin C as the standard, the incidence of contrast medium nephropathy at 24 h after surgery was 19.74%, the difference was statistically significant(χ^2=4.476, P=0.034);according to Europe Urogenital Radiology Association(2005) Contrast Media Guidelines Standard Evaluation: The sensitivity of serum cystatin C in diagnosing contrast media nephropathy is 93.75% and the specificity was 90.00%. Conclusion The detection of serum cystatin C before and after percutaneous coronary intervention has a high diagnostic sensitivity and specificity, and it can provide favorable conditions for the prevention and treatment of contrast nephropathy.
作者
房建斌
FANG Jian-bin(Department of Cardiology,Rudong People's Hospital,Rudong,Jiangsu Province,226400)
出处
《系统医学》
2020年第17期65-67,共3页
Systems Medicine
关键词
冠心病
经皮冠状动脉介入术
血清胱抑素C
对比剂肾病
临床价值
Coronary Heart Disease
Percutaneous Coronary Intervention
Serum Cystatin C
Contrast Nephropathy
Clinical Value
