摘要
萄糖调节蛋白78(GRP78)是首个被发现的内质网分子伴侣,同时被视为内质网应激反应的经典标志性蛋白分子,在细胞内发挥多重功能。目前已在肿瘤、大脑缺血再灌注损伤等病理组织器官中发现GRP78异常上调表达,GRP78作为肿瘤与脑血管缺血性疾病的治疗靶点的应用前景不可忽视。本文主要从GRP78的分子结构、正常生理功能、涉及的内质网应激反应相关机制、GRP78与肿瘤、缺血再灌注损伤的预后等方面进行综述,旨在揭示GRP78的功能作用,明确其在肿瘤、缺血再灌注损伤发生发展过程中的作用。
Glucose regulatory protein 78(GRP78)is the first endoplasmic reticulum molecular chaperone to be discovered,and it is also regarded as a classic protein molecule of endoplasmic reticulum stress response,which performs multiple functions in cells.At present,abnormally up-regulated expression of GRP78 has been found in tumors,cerebral ischemia-reperfusion injury and other pathological tissues and organs.The application prospect of GRP78 as a therapeutic target for tumors and cerebral ischemic diseases cannot be ignored.This article mainly reviews the molecular structure of GRP78,the normal physiological functions,the related mechanisms of endoplasmic reticulum stress response,GRP78 and tumors,and the prognosis of ischemia-reperfusion injury are reviewed in order to reveal the functional role of GRP78 and clarify its occurrence in tumors and ischemia-reperfusion injury role in the development process.
作者
陈晓殷
李文静
朱卓丽
李雄娟
黄焕森
CHEN Xiao-yin;LI Wen-jing;ZHU Zhuo-li;LI Xiong-juan;HUANG Huan-sen(Department of Anesthesiology,the Second Clinical College of Guangzhou Medical University,Guangzhou 511436,Guangdong,China;Department of Anesthesiology,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,Guangdong,China)
出处
《医学信息》
2020年第20期26-29,共4页
Journal of Medical Information
关键词
GRP78
内质网应激
肿瘤
缺血再灌注损伤
GRP78
Endoplasmic reticulum stress
Tumor
Ischemia-reperfusion injury
