摘要
SAPHO综合征(synovitis-acne-pustulosis-hyperostosis-osteitis syndrome)是一种罕见的自身免疫性疾病,是由滑膜炎、痤疮、脓疱病、骨肥厚、骨炎组成的一组慢性无菌性炎症综合征。由于其临床症状的高度异质性,诊治方案颇具挑战,随着近年来对该疾病认识的深入,相比传统的非甾体抗炎药(NSAIDs)、抗风湿类药物(DMARDs)、皮质类固醇等治疗药物,生物制剂以其安全、有效,以及对某一器官的迅速应答为SAPHO治疗提供了新的选择。本文通过大量检索国内外回顾性分析文献,探讨及汇总诊治SAPHO综合征的可行措施。
Synovitis-acne-pustulosis-hyperostosis-osteitis syndrome(SAPHO)is a rare autoimmune disease,a group of chronic aseptic inflammatory syndromes involving synovitis,acne,pustules,bone hypertrophy and osteitis.Due to the diversity of clinical symptoms,the treatment scheme is quite challenging.Compared with traditional non-steroidal anti-inflammatory drugs(NSAIDs),the disease-modifying antirheumatic drugs(DMARDs),corticosteroids and other treatments,biological agents provide new options for SAPHO treatment with their safety,effectiveness and rapid response to a certain organ.In this paper,the feasible measures for the diagnosis and treatment of SAPHO syndrome were summarized through a large number of domestic and international literature review.
作者
石素雨
刘晓红
宋来涛
杨惠
张倩倩
SHI Su-yu;LIU Xiao-hong;SONG Lai-tao;YANG Hui;ZHANG Qian-qian(Taian Area,The960 th Hospital of PLA,Taian271000,China)
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2020年第19期1783-1787,共5页
Orthopedic Journal of China
