摘要
B细胞特异性莫洛尼鼠白血病病毒整合位点1(blymphoma momlv insertion region 1,BMI1)是位于人类染色体10p12.2的一段基因序列,它是多梳组蛋白复合物1(polycomb repressive complex 1,PRC1)的重要组成成分之一。含有BMI1蛋白的复合物PRC1可以通过染色质重塑维持许多基因的转录抑制状态,对脑部各区域的神经发生产生影响。此外,BMI1蛋白作为神经系统中的重要转录因子之一,其基因表达水平的改变,对脑部神经系统疾病的进程有显著的影响。本综述旨在阐述BMI1基因对脑部侧脑室下区(subventricular zone,SVZ)、嗅球区、小脑区、皮层区以及视网膜区神经干细胞的自我更新、增殖和分化能力的影响,并且系统性地剖析了其对阿尔茨海默症和胶质母细胞瘤的影响机制。
Blymphoma momlv insertion region 1(BMI1)is a gene sequence located on the human chromosome 10 p12.2,which is an important component of the polycomb repressive complex 1(PRC1).PRC1,a complex containing BMI1 protein,can maintain the transcriptional repression status of many genes through chromatin remodeling,which has an effect on neurogenesis in various regions of the brain.In addition,BMI1 protein is one of the important transcription factors in the nervous system,and its gene expression level changing has a significant impact on the progress of brain neurological diseases.This review aims to elucidate the effect of BMI1 gene on the self-renewal,proliferation and differentiation of neural stem cells in the subventricular zone(SVZ),olfactory bulb,cerebellum,cortex and retinal regions of the brain.The mechanism of its effects on Alzheimer’s disease and glioblastoma was also discussed.
作者
孙长慧
惠洋
宁心
高旭
SUN Changhuil;HUI Yang;NING Xin;GAO Xu(Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Harbin Medical University,Harbin 150081,China;Ningxin Dental Clinic,Harbin 150080,China)
出处
《生命的化学》
CAS
CSCD
2020年第8期1314-1321,共8页
Chemistry of Life
基金
国家自然科学基金项目(81671255)。
