摘要
目的探讨拮抗剂方案中hCG日孕酮(P)水平对胚胎质量及妊娠结局的影响。方法回顾性分析1159例IVF助孕周期资料,比较hCG日P<1.5 ng/mL新鲜移植周期(A组)与P≥1.5 ng/mL全胚冷冻周期(B组)首次解冻后妊娠结局,及获卵数和胚胎质量差异;其次,当P在1.5~2.0 ng/mL时,比较新鲜移植周期(C组)与全胚冷冻周期(B1组)首次解冻后妊娠结局差异。结果与A组相比,B组D3优胚率、囊胚形成率,临床妊娠率和持续妊娠率差异均无统计学意义;B组平均获卵数明显高于A组[(14.41±7.06)vs.(11.36±4.92),P<0.01]。当P在1.5~2.0 ng/mL时,C组和B1组临床妊娠率(53.97%vs.50.00%)和持续妊娠率(46.03%vs.44.12%)差异无统计学意义。结论hCG日P升高对胚胎质量无明显影响;P在1.5~2.0 ng/mL时,新鲜周期移植和解冻周期移植妊娠结局相似。
Objective To investigate the effect of serum progesterone level on the day of hCG administration on embryo quality and pregnancy outcomes of cycles with GnRH antagonist protocol.Methods A total data of1159 IVF cycles were analyzed retrospectively.The difference of number of oocytes retrieved and embryos quality were compared between the fresh transfer cycles with serum progesterone<1.5 ng/mL on the hCG day(Group A)and"freeze all"cycles with progesterone≥1.5 ng/mL(Group B).Pregnancy outcomes between Group A and Group B in the first frozen-thawed embryo transfer(FET)cycles were also compared.In addition,when progesterone level on the hCG day was at 1.5~2.0 ng/mL,the difference of pregnancy outcomes was compared between the fresh transfer cycles(Group C)and the first FET cycles with"freeze all"strategy(Group B1).Results There were no significant differences in the rates of good-quality embryo on Day 3,blastocyst formation,clinical pregnancy and ongoing pregnancy of the first FET cycles between Group A and Group B.The average number of oocytes retrieved in Group B was more than that in Group A[(14.41±7.06)vs.(11.36±4.92),P<0.01].In addition,when progesterone level on the hCG day was at 1.5~2.0 ng/mL,there was no significant difference in clinical pregnancy rate(53.97%vs.50%)and ongoing pregnancy rate(46.03%vs.44.12%)of the cycles between Group C and Group B1.Conclusions The increase of progesterone level on the hCG day may have no significant effect on the embryo quality.When serum progesterone level is at 1.5~2.0 ng/mL,pregnancy outcomes of fresh transfer cycles are similar to those in the first FET cycles using"freeze all"strategy.
作者
殷慧群
曹振毅
姜宏
YIN Huiqun;CAO Zhenyi;JIANG Hong(Reproductive Medicine Center of Anhui NO.2 Provincial People′s Hospital,Hefei 230041,China;Reproductive Medicine Center of the 901st Hospital,Hefei 230032,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2020年第19期2667-2671,共5页
The Journal of Practical Medicine
基金
安徽省科技攻关计划项目(编号:1604a0802095)。
关键词
拮抗剂方案
孕酮
胚胎发育
妊娠结局
GnRH antagonist protocol
progesterone
embryo development
pregnancy outcome
