摘要
目的探讨加味酸枣仁汤对焦虑性失眠患者焦虑状态及5-HT、DA的影响.方法选取2018年2月—2020年2月接诊的100例焦虑性失眠患者,按随机数字表法将其分为比对组和研究组,各50例.比对组采用佐匹克隆药物治疗,研究组在比对组基础上采用加味酸枣仁汤治疗,均持续治疗1个月.比较2组临床疗效;比较2组治疗前后HAMA、PSQI评分及血清5-HT、DA水平变化;观察并记录治疗期间2组不良反应发生情况.结果研究组总有效率(96.00%)显著高于比对组(82.00%)(P<0.05);与治疗前比,治疗后2组HAMA、PSQI评分均降低,且研究组显著低于比对组(P<0.05);与治疗前比,治疗后2组血清5-HT、DA水平均升高,且研究组显著高于比对组(P<0.05);研究组不良反应发生率(12.00%)显著低于比对组(30.00%)(P<0.05).结论加味酸枣仁汤可调节焦虑性失眠患者5-HT、DA水平,改善焦虑状况,提高睡眠质量,疗效显著,且安全性良好.
Objective To investigate the effect of modified Suanzaoren decoction on anxiety state,5-HT and DA of patients with anxiety insomnia.Methods A total of 100 patients with anxiety insomnia admitted to our center from February 2018 to February 2020 were selected and divided into comparison group and study group,with 50 cases in each,according to the random number table method.The experimental group was treated with zopiclone drug,and the study group was treated with modified Suanzaoren decoction on the basis of the comparison group.All of which lasted for 1 month.The clinical efficacy of the two groups was compared.HAMA,PSQI scores and serum 5-HT and DA levels of the two groups were compared before and after treatment.The occurrence of adverse reactions in both groups was observed and recorded during treatment.Results The total effective rate of the study group(96.00%)was significantly higher than that of the comparison group(82.00%)(P<0.05).HAMA and PSQI scores of the two groups decreased after treatment compared with those before treatment,and the study group was significantly lower than the comparison group(P<0.05).Serum levels of 5-HT and DA in the two groups increased after treatment compared with before treatment,and the study group was significantly higher than the comparison group(P<0.05).The incidence of adverse reactions in the study group(12.00%)was significantly lower than that in the comparison group(30.00%)(P<0.05).Conclusion Modified Suanzaoren decoction can adjust the level of 5-HT and DA in patients with anxiety insomnia,improve the state of anxiety,improve the quality of sleep,has significant efficacy and good safety.
作者
李素英
韩君
LI Suying;HAN Jun(Department of Internal Medicine,Pingcheng District Maternal and Child Health and Family Planning Service Center,Shanxi Province,Datong 037008,China;Department of Traditional Chinese Medicine,the Fifth People's Hospital of Datong,Shanxi Province,Datong 037009,China)
出处
《光明中医》
2020年第17期2636-2638,共3页
GUANGMING JOURNAL OF CHINESE MEDICINE
关键词
焦虑性失眠
酸枣仁汤
焦虑
中医药疗法
anxiety insomnia
Suanzaoren decoction
anxiety
therapy of TCM
