摘要
目的应用磁共振脂肪定量技术评估女性腰椎骨质疏松程度与骨密度(BMD)的相关性。方法将121名健康女性研究对象按年龄分为21~30岁组(n=17)、31~40岁组(n=11)、41~50岁组(n=24)、51~60岁组(n=63)、61~70岁组(n=6)。以DXA测量L1-L4椎体骨密度,以VIBE-Dixon技术测量L1-L4椎体骨髓脂肪分数。比较不同组间骨髓脂肪分数差异,同时分别对骨髓脂肪分数与BMD、年龄进行相关性分析。另外,分别对BMD、骨髓脂肪分数与绝经年限做相关性分析。结果组间差异有统计学意义(F值:14.541,P<0.001)。骨髓脂肪分数与年龄之间存在相关性(r=0.659,P<0.001);骨密度随脂肪分数上升呈下降趋势;随绝经年限的延长,BMD呈下降趋势,骨髓脂肪分数呈上升趋势。结论VIBE-Dixon能定量测量妇女腰椎椎体脂肪含量,可间接评估骨质疏松程度;与DXA的结果具有相关性。
Objective To evaluate the correlation between the degree of lumbar osteoporosis and bone mineral density(BMD)in women measured using VIBE-Dixon technology.Methods One hundred and twenty-one healthy female subjects were divided into 21-30 years old group(n=17),31-40 years old group(n=11),41-50 years old group(n=24),51-60 years old group(n=63),and 61-70 years old group(n=6).BMD of the L1-L4 vertebral body was measured using dual-energy X-ray absorptiometry(DXA).The bone marrow fat fraction of L1-L4 vertebral body was measured using VIBE-Dixon technique.The differences of bone marrow fat fraction were compared among different groups.Meanwhile,the correlations between bone marrow fat fraction and BMD,between bone marrow fat fraction and age were analyzed,respectively.In addition,the correlation analysis on BMD,bone marrow fat fraction,and menopausal duration was performed.Results The differences among the groups were statistically significant(F value:14.541,P<0.001).There was a correlation between bone marrow fat fraction and age(r=0.659,P<0.001).BMD decreased with the increase of fat fraction.With the prolongation of menopause age,BMD decreased and bone marrow fat content increased.Conclusion VIBE-Dixon quantitatively measures the fat content of lumbar vertebra and indirectly evaluates the degree of osteoporosis.It is correlated with the DXA result.
作者
陆丰
倪建明
姜宇
赵艳军
吴文娟
张追阳
LU Feng;NI Jianming;JIANG Yu;ZHAO Yanjun;WU Wenjuan;ZHANG Zhuiyang(Department of Radiology,the Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University,Wuxi 214001,China;Department of Orthopedics,the Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University,Wuxi 214001,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2020年第9期1287-1290,共4页
Chinese Journal of Osteoporosis
