摘要
目的探讨奥曲肽联合凝血酶治疗肝硬化合并上消化道出血患者的临床疗效。方法选择2017年5月至2019年5月我院收治的54例肝硬化合并上消化道出血的患者,随机分为研究组与对照组,各27例。两组患者均给予常规基础治疗,研究组在此基础上配合使用奥曲肽联合凝血酶治疗,对照组在此基础上配合使用奥曲肽治疗。分析比较两组患者的临床疗效、治疗后肝功能指标、临床指标以及不良反应发生情况。结果研究组患者的治疗总有效率88.89%高于对照组的51.85%(P<0.05)。研究组患者治疗后的天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)、谷氨酞转移酶(GGT)、总胆红素(TBiL)、直接胆红素(DBiL)水平低于对照组,血清总蛋白(TP)、白蛋白(ALB)水平高于对照组(P<0.05)。研究组患者住院时间、输血量、止血时间均优于对照组(P<0.05)。研究组患者不良反应发生率低于对照组(P<0.05)。结论肝硬化合并上消化道出血患者使用奥曲肽联合凝血酶治疗的临床疗效显著,可以降低炎性反应,缩短止血时间,降低出血量,有效改善患者的肝功能指标,促进患者康复,缩短住院时间,并且不良反应少,更为安全可靠。
Objective To investigate the clinical effect of otreotide combined with thrombin in the treatment of patients with cirrhosis with upper gastrointestinal bleeding.Methods 54 patients with liver cirrhosis and upper gastrointestinal bleeding admitted to our hospital from May 2017 to May 2019 were randomly divided into a study group and a control group,with 27 cases in each group.Both groups of patients were given conventional basic treatment.The study group was treated with octreotide combined with thrombin on this basis,and the control group was treated with octreotide on this basis.To analyze and compare the clinical efficacy,liver function indexes after treatment,clinical indexes and adverse reactions of the two groups of patients.Results The total effective rate of treatment in the study group was 88.89%,which was higher than 51.85%in the control group(P<0.05).The levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),alkaline phosphatase(ALP),gamma glutamyl transpeptidase(GGT),total bilirubin(TBiL)and direct bilirubin(DBiL)after treatment in the study group were lower than that of in the control group,and the serum total protein(TP)and albumin(ALB)levels were higher than that of in the control group(P<0.05).The hospitalization time,blood transfusion volume and hemostasis time of patients in the study group were better than those in the control group(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion The clinical effect of octreotide combined with thrombin in patients with cirrhosis and upper gastrointestinal bleeding is significant,which can reduce inflammation,shorten hemostasis time,reduce bleeding,and effectively improve the liver function of patients,promote patient recovery,and shorten hospital stay.And the adverse reactions are less,it is more safer and reliable.
作者
邢凤媛
XING Fengyuan(Shenyang Red Cross Hospital,Shenyang 110013,China)
出处
《中国医药指南》
2020年第25期55-56,共2页
Guide of China Medicine
关键词
肝硬化合并上消化道出血
奥曲肽
凝血酶
不良反应
肝功能
Cirrhosis combined with upper gastrointestinal bleeding
Octreotide
Thrombin
Adverse reactions
Liver function
