摘要
评价左旋氧氟沙星的临床有效性与安全性。采用前瞻性随机对照试验方法。试验药为左旋氧氟沙星，每次200－300mg，静脉滴注，每日2次。对照药为环丙沙星，每次200－400mg，静脉滴注，每日2次。疗程均为7－14d。结果为试验组38例与对照组35例的两组治愈率分别是76．3％与68．6％。有效率分别是97．4％与97．1％，细菌清除率分别是88．6％与89．7％。药物不良反应发生率分别是79％（3／38）与5．6％（2／36），统计学均无显著性差异。结论为左旋氧氟沙皇对于临床常见的呼吸道、泌尿道、肠道细菌感染是一种安全、有效的药物。
To evaluate the clinical efficacy and safety of levofloxacin. A prospectiverandomized-controlled clinical trial was carried out. Levofloxacin as a trial drug wasadministered in 200~300 mg doses, twice a day by iv. infusion. Ciprofloxacin as a controldrug was 200~400mg, twice a day by iv infusion. The treatment lasted for 7~14 days.Resultst 38 patients were treated with levofloxacin and 35 patients were treated withciprofloxacin. The clinical cure rates of the two groups were 76.3% and 68.6% respectively.The clinical effcacy rates were 97.4% and 97. 1 % respectively. The bacterial clearancerates were 88.6% and 89.7% respectiveIy. The adverse drug reaction rates were 7.9%(3/38)and 5.6%(2/36) respectively. There were no statistical differences. Levofloxalin is a safeand effective drug in the treatment of infections of the respiratory, urinary and alimentarytracts.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2000年第3期168-171,共4页
The Chinese Journal of Clinical Pharmacology
