摘要
目的分析依达拉奉联合阿司匹林对脑卒中患者神经功能缺损及血液流变学的影响。方法将115例急性脑卒中患者采用随机抽签法分为对照组(56例)和观察组(59例),对照组口服阿司匹林治疗,观察组给予依达拉奉联合阿司匹林治疗;连续治疗2周,比较2组的近期临床疗效、治疗前后神经功能缺损程度及日常生活能力、血液流变学、血小板聚集率、血清超氧化物歧化酶(SOD)、丙二醛(MDA)、脑源性神经营养因子(BNDF)、酪氨酸激酶受体B(TrkB)、超敏C反应蛋白(hs-CRP)水平和不良反应发生情况。结果观察组总有效率(88.13%)明显高于对照组(73.21%);治疗后2组NIHSS评分均降低,ADL评分均升高,观察组NIHSS评分明显低于对照组,ADL评分明显高于对照组;治疗后2组全血黏度、血浆黏度、纤维蛋白原水平和血小板聚集率均较治疗前明显降低,观察组较对照组降低更明显;治疗后2组MDA水平和hs-CRP水平均降低,观察组较对照组降低更明显;2组SOD水平均上升,且观察组明显高于对照组(P<0.05)。对照组不良反应发生率(10.71%)低于观察组(11.86%),但差异无统计学意义(P>0.05)。结论依达拉奉联合阿司匹林可有效改善急性缺血性脑卒中患者血液流变学和血小板聚集、增强氧化应激能力,提高BNDF和TrkB水平,降低hs-CRP水平,改善神经功能缺损的临床疗效确切,其较单用阿司匹林治疗效果更佳,具有临床推广价值。
Objective To analyze the effect of edaravone combined with aspirin on neurological deficit and hemorheology in stroke patients.Methods 115 cases of patients with acute cerebral apoplexy were grouped and divided into control group(56 cases)and observation group(59 cases)randomly.The control group were given aspirin orally,while the observation group was given edaravone in combination of aspirin,treated 2 weeks in a row.The clinical curative effect of nerve function defect degree,daily life ability,hemorheology and platelet aggregation rate,serum levels of superoxide dismutase(SOD),malondialdehyde(MDA),brain-derived neurotrophic factor(BNDF),tyrosine kinase receptor B(TrkB)and hypersensitive C-reactive protein(hs-CRP),and adverse reactions were compared before and after treatment.Results The total effective rate of the observation group(88.13%)was significantly higher than that of the control group(73.21%).After treatment,NIHSS scores were decreased in both groups,and ADL score was increased in both groups.Compared with control group,NIHSS score in the observation group was significantly lower and ADL score was significantly higher.After treatment,the whole blood viscosity,plasma viscosity,fibrinogen level and platelet aggregation rate of the 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group.After treatment,MDA activity and hs-CRP levels in both groups were decreased,and those in the observation group were significantly lower than in the control group.SOD levels in both groups were increased,and those in the observation group were significantly higher than in the control group(P<0.05).The incidence of adverse reactions in the control group(10.71%)was lower than that in the observation group(11.86%),but the difference was not statistically significant(P>0.05).Conclusion The combination of edaravone with aspirin improves hemorheology,reduces platelet aggregation,enhances the capacity of oxidative stress,improves the level of BNDF and TrkB,
作者
高行军
周锦
边莹
罗亚妮
张媛媛
赵锐
辛莉
GAO Xingjun;ZHOU Jin;BIAN Ying;LUO Yani;ZHANG Yuanyuan;ZHAO Rui;XIN Li(Department of Pharmacy,the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China)
出处
《西北药学杂志》
CAS
2020年第5期748-752,共5页
Northwest Pharmaceutical Journal
基金
陕西省科学技术研究发展计划项目(编号:2015SF223)。
