摘要
目的探讨血清胎盘生长因子(PLGF)水平与子痫前期胎儿生长受限的关联性。方法分析2016年5月至2019年5月期间于本院分娩的子痫前期孕妇228例,按分娩的新生儿体重分为观察组(体重小于胎龄儿)与对照组(体重正常)。抽母血及脐血测定血清胎盘生长因子水平,单变量及多变量回归分析血清PLGF水平与子痫前期胎儿生长受限的关联性。结果观察组孕妇血清PLGF水平为(40.41±1.04)ng/L,而对照组为(36.48±1.12)ng/L,观察组明显高于对照组,差异有统计学意义(P<0.05);观察组新生儿脐血PLGF水平为(40.48±1.53)ng/L,明显高于对照组的(35.62±0.89)ng/L,差异有统计学意义(P<0.05)。单变量分析的结果显示高血压、吸烟、孕妇血清及新生儿脐血PLGF水平均与子痫前期胎儿生长受限正相关(P<0.05);而多变量分析的结果表明高血压、孕妇血清及新生儿脐血PLGF水平均与子痫前期胎儿生长受限正相关(P<0.05)。结论孕妇血清及新生儿脐血PLGF水平与子痫前期胎儿生长受限呈正相关,可作为诊断子痫前期胎儿生长受限的指标。
Objective To investigate the relationship between serum placenta growth factor(PLGF level and fetal growth restriction in preeclampsia. Methods A retrospective analysis of 228 preeclampsia pregnant women who were delivered to our hospital from May 2016 to May 2019 was divided into the observation group(weight less than gestational age)and the control group(normal weight). Serum placental growth factor level was measured by maternal blood and cord blood,and univariate and multivariate regression analysis was used to judge the correlation between serum PLGF level with fetal growth restriction in preeclampsia. Results The serum PLGF level of the pregnant women in the observation group was 40.41± 1.04 ng/L,36.48±1.12 ng/L in the control group. The observation group was significantly higher than the control group,the difference was statistically significant(P<0.05). The level of PLGF in cord blood was 40.48 ±1.53 ng/L,which was significantly higher than that in the control group(35.62±0.89 ng/L). The difference was statistically significant(P<0.05). The results of univariate analysis showed that hypertension,smoking,maternal serum and neonatal cord blood PLGF level were positively correlated with preeclamptic fetal growth restriction(P<0.05);multivariate analysis showed high blood pressure,maternal serum and the PLGF level of cord blood in neonates was positively correlated with fetal growth restriction in preeclampsia(P<0.05). Conclusion The level of PLGF in pregnant womens serum and neonatal cord blood is positively correlated with fetal growth restriction in preeclampsia,and can be used as an indicator to diagnose fetal growth restriction in preeclampsia.
作者
万雪华
马爱娟
WAN XueHua;MA AiJuan(Department of Obstetrics and Gynecology,Heze Second Peoples Hospital,Heze,Shandong,China,274000)
出处
《分子诊断与治疗杂志》
2020年第9期1192-1194,1199,共4页
Journal of Molecular Diagnostics and Therapy
基金
吴阶平医学基金会临床科研专项资助基金(320.6750.18565)。
关键词
血清胎盘生长因子
子痫前期
胎儿生长受限
关联性
Serum placental growth factor
Preeclampsia
Fetal growth restriction
Correlation
