摘要
目的探讨子痫前期外周血葡萄糖转运蛋白-1(GLUT-1)的表达水平及其与代谢指标的相关性。方法选取2017年3月至2019年4月本院收治的100例子痫前期患者设为子痫前期组,另选取同期于本院健康体检的人群100例,设为对照组,测定所有受试者GLUT-1表达水平及代谢相关指标,比较两组受试者GLUT-1表达水平及代谢指标水平;采用Pearson线性方程分析GLUT-1表达水平与子痫前期代谢指标间的相关性。结果子痫前期组GLUT-1 m RNA及蛋白表达水平高于对照组,差异有统计学意义(P<0.05);代谢指标乳酸水平、丙酮酸水平子痫前期组高于对照组,差异有统计学意义(P<0.05)。Pearson相关分析提示GLUT-1 mRNA及蛋白与子痫前期代谢指标乳酸水平、丙酮酸水平呈正相关(P<0.05)。结论 GLUT-1 mRNA及蛋白表达水平在子痫前期患者外周血中含量高于健康人群,与子痫前期代谢指标乳酸水平、丙酮酸水平呈正相关,推测GLUT-1参与了妊高症的发生发展。
Objective To investigate the expression level of glucose transporter-1(GLUT-1)in peripheral blood of pregnancy preeclampsia and its correlation with metabolic indexes.Methods Selected 100 cases of pre-eclampsia patients admitted to this hospital from March 2017 to April 2019 were included as the preeclampsia group,and 100 cases of the population who underwent a physical examination in this hospital during the same period were selected as the control group,and all subjects were measured The expression level of GLUT-1 and metabolic indicators were compared between 2 groups of subjects.The expression level of GLUT-1 and the levels of metabolic indicators were compared;the Pearson linear equation was used to analyze the correlation between the expression level of GLUT-1 and the metabolic indicators of preeclampsia.Results The expression levels of GLUT-1 mRNA and protein in the preeclampsia group were higher than those in the control group,the difference was statistically significant(P<0.05);the levels of metabolic indexes,lactic acid,pyruvate levels in the preeclampsia group were higher than those in the control group,the difference was statistically significant(P<0.05).Pearson correlation analysis showed that the expression level of GLUT-1 mRNA and protein were positively correlated with the levels of lactic acid,pyruvate,triglycerides,and low-density lipoprotein,which are metabolic indicators of preeclampsia(P<0.05).Conclusion The level of GLUT-1 mRNA and protein in the peripheral blood of patients with preeclampsia is higher than that of healthy people,and it is positively correlated with the levels of lactic acid,pyruvate,which are metabolic indicators of preeclampsia.It is speculated that GLUT-1 is involved The occurrence and development of pregnancy-induced hypertension.
作者
罗沛芬
陈小兰
黄文
LUO Peifen;CHEN Xiaolan;HUANG Wen(Department of Obstetrics and Gynecology,Dongguan People's Hospital,Dongguan,Guangdong,China,52300)
出处
《分子诊断与治疗杂志》
2021年第4期647-650,共4页
Journal of Molecular Diagnostics and Therapy
关键词
妊高症
子痫前期
葡萄糖转运蛋白-1
代谢指标
Pregnancy-induced hypertension
Preeclampsia
Glucose transporter-1
Metabolic index
