摘要
作为常见的空气污染物,含硫气体分子硫化氢(hydrogen sulfide,H2S)和二氧化硫(sulfur dioxide,SO2)的毒性效应被广泛证实。在哺乳动物体内,H2S和SO2可由含硫氨基酸代谢内源性生成,参与心血管、消化、内分泌等多个系统的生理和病理生理过程。随着研究的不断深入,含硫气体分子的中枢调控功能不断被报道,广泛参与海马长时程增强易化、神经元凋亡和坏死、神经内分泌调节,与阿尔兹海默症、学习与记忆、抑郁症等关系密切。本文简单介绍了H2S和SO2在生物体的生成代谢途径,重点综述了上述两种含硫气体分子在中枢神经系统的调控功能及其机制。
Hydrogen sulfide(H2S) and sulfur dioxide(SO2), as two common air pollutants, have been widely investigated for their toxicological effects. In mammals, H2S and SO2, which can be endogenously derived from sulfur-containing amino acid in vivo, have been confirmed to participate many kinds of physiological and pathophysiological processes. Evidences have been accumulated to demonstrate that sulfur-containing gaseous molecules play an important role in central nervous system, which are widely involved in the long-term potentiation of hippocampus, neuron apoptosis and necrosis, neuroendocrine regulation and are closely related to Alzheimer’s disease, learning and memory, depression. This article overviews the metabolic pathways of H2S and SO2 in vivo and outlines the regulatory function and mechanism of sulfur-containing gas molecules in central nervous system.
作者
史晓瑞
赵鹏辉
苏玉娇
李雯淑雅
史崇霖
王歆皓
史海水
SHI Xiaorui;ZHAO Penghui;SU Yujiao;LI Wenshuya;SHI Chonglin;WANG Xinhao;SHI Haishui(Neuroscience Research Center,Institute of Medical and Health Science of HeBMU,Hebei Medical University,Shijiazhuang,050017,China)
出处
《中国药物依赖性杂志》
CAS
CSCD
2020年第4期262-267,共6页
Chinese Journal of Drug Dependence
基金
国家自然科学基金项目(81771462)
河北省杰出青年基金项目(H2018206119)
河北医科大学大学生创新性实验项目(USIP2018069,USIP2020008)
河北省高校百名优秀创新人才支持计划(SLRC2019047)。
关键词
含硫气体分子
硫化氢
二氧化硫
神经保护
认知
抑郁症
sulfur-containing gaseous molecules
hydrogen sulfide
sulfur dioxide
neuroprotection
cognition
depression
