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早期冠状动脉内应用硝酸甘油和地尔硫卓对STEMI病人PCI术后心肌血流灌注的影响 被引量:5

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摘要 目的探讨早期冠状动脉内应用硝酸甘油和地尔硫卓对经皮冠状动脉介入(PCI)治疗的急性ST段抬高型心肌梗死(STEMI)病人术后心肌血流灌注的影响。方法选取鹤壁市人民医院2017年1月—2017年12月收治的拟实施PCI治疗的70例STEMI病人,采用随机数字表法分为干预组和对照组,各35例。干预组在导丝通过病变血管后采用指引管注入硝酸甘油200μg、地尔硫卓200μg,随后开展常规介入治疗。对照组在导丝通过病变血管后采用指引管注入20 mL生理盐水,随后开展常规介入治疗。比较两组术后心肌梗死溶栓治疗(TIMI)血流分级、校正的TIMI计帧数(CTFC)、血清肌酸激酶同工酶(CK-MB)的峰值及达峰时间、血清C反应蛋白(CRP)、白细胞介素-10(IL-10)、脑钠肽(BNP)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)。结果PCI术后,干预组TIMI血流分级明显优于对照组(P<0.05);PCI术后,干预组CTFC帧数血清CRP、IL-10、BNP水平及CK-MB峰值均明显低于对照组(P<0.05),达峰时间较对照组缩短(P<0.05);PCI术后,干预组LVEDD值低于对照组(P<0.05),LVEF值高于对照组(P<0.05)。结论对于拟实施PCI治疗的STEMI病人,早期冠状动脉内应用硝酸甘油和地尔硫卓可改善病人心肌血流灌注。
机构地区 鹤壁市人民医院
出处 《中西医结合心脑血管病杂志》 2020年第17期2864-2867,共4页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
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  • 1申华,周玉杰.2011欧洲心脏病学会非ST段抬高型急性冠脉综合征处理指南更新解读[J].中国医学前沿杂志(电子版),2011,3(5):97-99. 被引量:20
  • 2Gabriel Steg,Stefan K. James,Dan Atar.ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. European Heart Journal . 2012 被引量:2
  • 3Ito N,Nanto S,Doi Y,et al.Beneficial effects of intracoronary nicorandil on microvascular dysfunction after primary percutaneous coronary intervention:demonstration of its superiority to nitroglycerin in a cross-over study. Cardiovascular Drugs . 2013 被引量:1
  • 4Hirohata A,Yamamoto K,Hirose E,et al.Nicorandil prevents microvascular dysfunction resulting from PCI in patients with stable angina pectoris:a randomized study. Eurolntervention . 2014 被引量:1
  • 5Wu M,Huang Z,Xie H, et al.Nicorandil in patients with acutemyocardial infarction undergoing primary percutaneous coronaryintervention: a systematic review and meta-analysis. PLoS One . 2013 被引量:1
  • 6Qiang Fu,Wen Lu,Yi-jie Huang,Qiang Wu,Lin-guang Wang,Hai-bo Wang,Shu-zhong Jiang,Yan-jiong Wang.??Verapamil Reverses Myocardial No-Reflow After Primary Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction(J)Cell Biochemistry and Biophysics . 2013 (3) 被引量:1
  • 7Derek J. Hausenloy.??Cardioprotection Techniques: Preconditioning, Postconditioning and Remote Con-ditioning (Basic Science)(J)Current Pharmaceutical Design . 2013 (25) 被引量:1
  • 8O’’Gara PT,Kushner FG,Ascheim DD,et al.2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction:a report of the American College of Cardiology Foundation/Amencan Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology . 2013 被引量:1
  • 9Giampaolo Niccoli,Stefano Rigattieri,Maria Rosaria De Vita,Marco Valgimigli,Pierfrancesco Corvo,Franco Fabbiocchi,Enrico Romagnoli,Alberto Ranieri De Caterina,Giuseppe La Torre,Paolo Lo Schiavo,Fabio Tarantino,Roberto Ferrari,Fabrizio Tomai,Paolo Olivares,Nicola Cosentino,Domenico D’Amario,Antonio Maria Leone,Italo Porto,Francesco Burzotta,Carlo Trani,Filippo Crea.??Open-Label, Randomized, Placebo-Controlled Evaluation of Intracoronary Adenosine or Nitroprusside After Thrombus Aspiration During Primary Percutaneous Coronary Intervention for the Prevention of Microvascular Obstruction in Acute Myocardial Infarction(J)JACC: Cardiovascular Interventions . 2013 (6) 被引量:1
  • 10Pierluigi Tricoci,Sergio Leonardi,Jennifer White,Harvey D. White,Paul W. Armstrong,Gilles Montalescot,Robert P. Giugliano,C. Michael Gibson,Frans Van de Werf,Robert M. Califf,Robert A. Harrington,Eugene Braunwald,Kenneth W. Mahaffey,L. Kristin Newby.??Cardiac Troponin After Percutaneous Coronary Intervention and 1-Year Mortality in Non–ST-Segment Elevation Acute Coronary Syndrome Using Systematic Evaluation of Biomarker Trends(J)Journal of the American College of Cardiology . 2013 (3) 被引量:1

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