摘要
目的:研究通阳宣痹汤治疗痰瘀互结型非ST段抬高型急性冠脉综合征的临床效果。方法:选取我院2019年1月~2020年1月收治的91例痰瘀互结型非ST段抬高型急性冠脉综合征患者作为研究对象,使用随机数字表法将其分为研究组(n=46例)与对照组(n=45例)。比较两组患者治疗前后肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及超敏C反应蛋白(hs-CRP)等炎症因子表达水平变化;比较两组患者治疗前后磷酸肌酸同工酶(CK-MB)、肌酸磷酸激酶(CK)及基质金属蛋白酶-9(MMP-9)等心肌损伤标志物变化情况;记录并比较两组患者治疗前后左心室射血分数(LEVF)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LEVDD)及每分心输出量(CO)等心功能指标表达水平变化;比较两组患者治疗前后中医证候积分变化情况;比较两组患者治疗后心血管事件发生情况。结果:两组患者治疗前TNF-α、IL-6及hs-CRP表达水平无显著差异(P>0.05),治疗后研究组患者TNF-α、IL-6及hs-CRP表达水平均低于对照组(P<0.05);两组患者治疗前CK-MB、CK及MMP-9等表达水平无显著差异(P>0.05),治疗后研究组患者CK-MB、CK及MMP-9等表达水平均低于对照组(P<0.05);两组患者治疗前LEVF、LVESD、LEVDD及CO表达水平无显著差异(P>0.05),治疗后研究组患者LEVF、CO等指标表达水平高于对照组(P<0.05),LVESD、LEVDD等指标表达水平低于对照组(P<0.05);两组患者治疗前中医症候积分无显著差异(P>0.05),治疗后研究组患者中医症候积分均低于对照组(P<0.05);研究组患者治疗后心血管事件总发生率10.87%显著低于对照组28.89%(P<0.05)。结论:通阳宣痹汤可有效促进痰瘀互结型非ST段抬高型急性冠状动脉综合征患者血清炎症水平恢复并改善其临床症状,促进患者心肌损伤标志物及心功能指标的恢复,减少其心血管事件发生率。
Objective:To study the clinical effect of using Tongyang Xuanbi Decoction in the treatment of non-ST-segment elevation acute coronary syndrome of intermingled phlegm-blood stasis type.Methods:Ninety-one patients with non-ST-segment elevation acute coronary syndrome of intermingled phlegm-blood stasis type who were admitted to our hospital from January 2019 to January 2020 were selected as the research subjects,and they were divided into a study group(n=46)and a controlled group(n=45)by using the random number table method.The expression levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)were compared between the two groups before and after treatment.The changes of myocardial injury markers such as creatine phosphate isoenzyme-MB(CK-MB),creatine phosphokinase(CK)and matrix metalloproteinase-9(MMP-9)were compared between the two groups of patients before and after treatment.The changes in expression levels of cardiac function indicators such as left ventricular ejaculation fraction(LEVF),left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LEVDD)and cardiac output per min(CO)were recorded and compared between the two groups before and after treatment.The TCM syndromes scores of the two groups were compared before and after treatment,and the occurrence of cardiovascular events were compared between the two groups of patients after treatment.Results:There were no significant differences in the expression levels of TNF-α,IL-6 and hs-CRP between the two groups before treatment(P>0.05).After treatment,the expression levels of TNF-α,IL-6 and hs-CRP in study group were lower than those in controlled group(P<0.05).There were no significant differences in the expression levels of CK-MB,CK and MMP-9 between the two groups before treatment(P>0.05),and the expression levels of CK-MB,CK and MMP-9 in the study group after treatment were lower than those in the controlled group(P<0.05).There were no significant differences in the expressi
作者
缪志静
周云
张超
施珊岚
关敬树
MIAO Zhijing;ZHOU Yun;ZHANG Chao(epartment of Cardiology,Shanghai Baoshan Integrated Chinese and Western Medicine Hospital,Shanghai 201999,China)
出处
《四川中医》
2022年第10期77-80,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
上海市卫生健康委员会卫生行业临床研究专项(202040398)
关键词
通阳宣痹汤
痰瘀互结型
急性冠脉综合征
临床观察
Tongyang Xuanbi Decoction
Intermingled phlegm-blood stasis type
Acute coronary syndrome
Clinical observation
