摘要
目的为祖师麻后交联凝胶贴膏在贮存运输过程中的温度条件提供科学依据。方法以线性粘弹区、模量、屈服应力、相位角、复合黏度、蠕变柔量作为评价指标,通过高级旋转流变仪对祖师麻后交联凝胶贴膏基质进行振幅扫描、频率扫描、温度扫描和蠕变测试,分别得到样品在室温、-20℃及-50℃下贮存1、3、8、13 d的弹性模量、黏性模量、相位角、复合黏度、蠕变柔量、屈服应力的相关数据。结果祖师麻后交联凝胶贴膏所有样品均表现为弹性特征,状态稳定;经不同条件贮存后状态依旧稳定,分散性更好;贮存8、13d时样品的剥离强度减弱;-50℃下贮存13d时样品保型性降低。结论含后交联凝胶基质的祖师麻贴膏在0℃以下存放3 d时,状态稳定,分散性、初黏力、剥离强度和保型性良好。
Objective To provide scientific basis for the temperature condition of Daphnes Giraldii Cortex(DGC) post-cross-linked gel plaster during storage and transportation. Methods Taking linear viscoelastic region, modulus, yield stress, phase angle, composite viscosity and creep compliance as evaluation indexes, amplitude scanning, frequency scanning, temperature scanning and creep testing were carried out on the cross-linked gel plaster matrix after DGC by an advanced rotary rheometer, and relevant data of elastic modulus, viscosity modulus, phase angle, composite viscosity, creep compliance and yield stress of the samples which were stored at room temperature,-20 ℃ and-50 ℃ for 1, 3, 8, and 13 d were respectively obtained. Results All samples of DGC post-crosslinking gel plaster showed elastic characteristics and stable state. After storage under different conditions, the state is still stable and the dispersibility is better. The peel strength of samples stored for 8 d and 13 d was decreased. The retention of samples stored at-50 ℃ for 13 d was decreased. Conclusion DGC plaster containing post-crosslinked gel matrix had stable state, good dispersibility, initial adhesion, peel strength and shape retention when samples were stored below 0 ℃ for 3 d.
作者
李真真
万玲娟
王继龙
魏舒畅
刘晓霞
石盘棋
孙晓燕
LI Zhen-zhen;WAN Ling-juan;WANG Ji-long;WEI Shu-chang;LIU Xiao-xia;SHI Pan-qi;SUN Xiao-yan(Research Center of traditional Chinese Medicine Pharmaceutical Technology and Engineering of Gansu Province,Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第13期3457-3464,共8页
Chinese Traditional and Herbal Drugs
基金
甘肃省基础研究创新群体项目(1506RJIA034)。
关键词
祖师麻
后交联凝胶贴膏
流变性能
温度条件
稳定性
贮存时间
弹性模量
黏性模量
相位角
复合黏度
蠕变柔量
屈服应力
保型性
Daphnes Giraldii Cortex
post-crosslinking gel plaster
rheological properties
temperature conditions
stability
storage time
modulus of elasticity
viscous modulus
phase angle
compound viscosity
creep compliance
yield stress
type retention
