摘要
目的通过对35例肺癌脑转移患者行18F-FDG PET/CT多时相显像,探讨各定量参数最佳采集前代谢时间。方法基于视觉分析法制定出本实验的入组条件,按入组条件搜集2019年8月至11月间临床怀疑肺腺癌(经病理证实)颅内转移需行18F-FDG PET/CT显像患者35例,行常规PET/CT全身显像及2、4、6 h头部多时相显像,对半定量参数SUVmax、MTV40%、T/NT值的走势行折线图分析和统计学比较。结果4个时相SUVmax值分别为7.15±0.74、8.51±0.56、10.37±1.01、9.17±1.01,MTV40%值分别为5.92±5.02、6.50±5.36、5.30±4.42和4.52±4.10 cm^3,各时相测量值间差异具有统计学意义(P<0.001)。而且,SUVmax与MTV40%随循环时间延长均呈现先升后降的趋势,峰值拐点分别出现在4 h和2 h。T/NT值分别为0.84±0.15、1.07±0.20、1.61±0.23、1.97±0.50,各时相计算值间差异具有统计学意义(P<0.001);随循环时间延长T/NT值保持波动上升趋势。结论在肺癌脑转移患者18F-FDGPET/CT显像时,延迟采集可以解决因正常脑组织生理代谢过高而导致的常规显像所得图像对比度无法满足诊断需要的问题。且在做定量诊断以及疗效评价时,2 h延迟显像测算出的SUVmax值以及4 h延迟显像测算出的MTV值更加具有代表性。
Objective To explore the best metabolic time before collection of quantitative parameters by 18F-FDG PET/CT multi-phase imaging in 35 patients with brain metastases from lung cancer.Methods From August to November 2019,35 patients with clinically suspected intracranial metastases of lung adenocarcinoma(confirmed by pathology)who needed 18F-FDG PET CT imaging were collected.All patients underwent conventional PET/CT whole-body imaging and head multi phase imaging at 2,4 and 6 h.The trend of semi quantitative parameters SUVmax,MTV40%and T/NT were analyzed and compared statistically.Results The SUVmax values of the four phases were 7.15±0.74,8.51±0.56,10.37±1.01,9.17±1.01,the MTV 40%values were 5.92±5.02,6.50±5.36,5.30±4.42,and 4.52±4.10 cm3,the T/NT values were 0.84±0.15,1.07±0.20,1.61±0.23,1.97±0.50,and each time The difference between the phase measurements was statistically significant(all P<0.001).Moreover,SUVmax and MTV40%both showed a trend of first rise and then fall with the increase of cycle time,and the peak inflection points appeared at 4 h and 2 h,respectively,while the T/NT value was maintained rising trend.Conclusion In the 18F-FDG PET/CT imaging of patients with brain metastasis of lung cancer,delayed acquisition can solve the problem that the contrast of conventional imaging images cannot meet the diagnostic needs due to the excessive physiological metabolism of normal brain tissue.And when doing quantitative diagnosis and evaluation of therapeutic effect,the SUVmax value calculated by 2 h delayed imaging and the MTV value calculated by 4 h delayed imaging are more representative.
作者
陆皓
程祝忠
王丹
龙海飘
陈世容
姚玉唐
LU Hao;CHENG Zhuzhong;WANG Dan;LONG Haipiao;CHEN Shirong;YAO Yutang(PET/CT Center,Sichuan Cancer Hospital,Chengdu Sichuan 610041,China)
出处
《中国医疗设备》
2020年第9期93-96,共4页
China Medical Devices
基金
四川省应用基础重点项目(2017JY0081)
四川省干部保健科研课题(2018-803)。
