摘要
目的分析凝血相关指标在新生儿弥散性血管内凝血早期诊断中的应用价值。方法选取48例新生儿弥散性血管内凝血患儿作为实验组,再选取同期于本院分娩的健康新生儿40例作为对照组。两组均检测血浆凝血酶-抗凝血酶复合物(TAT)、D-二聚体(D-D)、纤维蛋白原降解产物(FDP)水平并进行对比,实验组给予小剂量肝素抗凝治疗,对比治疗前后的TAT、D-D、FDP水平。结果实验组TAT、D-D、FDP水平分别为(8.12±1.39)μg/L、(672.4±53.4)μg/L、(413.4±64.5)mg/L,均高于对照组的(2.36±1.02)μg/L、(234.8±16.9)μg/L、(12.6±4.3)mg/L,差异有统计学意义(P<0.05)。治疗后,实验组TAT、D-D、FDP水平分别为(2.68±0.45)μg/L、(245.1±17.8)μg/L、(11.8±3.4)mg/L,均低于治疗前的(8.12±1.39)μg/L、(672.4±53.4)μg/L、(413.4±64.5)mg/L,差异有统计学意义(P<0.05)。结论新生儿弥散性血管内凝血患儿TAT、D-D、FDP水平异常升高,可作为早期诊断和监测预后的重要指标。
Objective To analyze the value of plasma thrombin-antithrombin complex,D-dimer,fibrinogen degradation product detection in early diagnosis of disseminated intravascular coagulation in neonates.Methods There were 48 neonates with disseminated intravascular coagulation as the experimental group,and another 40 healthy neonates as the control group.The levels of plasma thrombin-antithrombin(TAT)complex,D-dimer(D-D),and fibrinogen degradation products(FDP)of the two groups were detected and compared.The experimental group was treated with low-dose heparin anticoagulation therapy,and TAT,D-D and FDP levels before and after treatment were compared.Results TAT,D-D and FDP levels of the experimental group were(8.12±1.39)μg/L,(672.4±53.4)μg/L and(413.4±64.5)mg/L respectively,which were higher than those of the control group(2.36±1.02)μg/L,(234.8±16.9)μg/L and(12.6±4.3)mg/L,and the difference was statistically significant(P<0.05).After treatment,TAT,D-D and FDP levels of the experimental group were(2.68±0.45)μg/L,(245.1±17.8)μg/L and(11.8±3.4)mg/L,which were all lower than those before treatment(8.12±1.39)μg/L,(672.4±53.4)μg/L and(413.4±64.5)mg/L,and the difference was statistically significant(P<0.05).Conclusion Abnormally elevated levels of TAT,D-D,and FDP in neonates with disseminated intravascular coagulation can be used as important indicators for early diagnosis and prognosis monitoring.
作者
李全培
冯荣波
LI Quan-pei;FENG Rong-bo(Xinyi People’s Hospital,Xinyi 525300,China)
出处
《中国现代药物应用》
2020年第18期45-47,共3页
Chinese Journal of Modern Drug Application
