摘要
目的研究普瑞巴林对帕金森病伴慢性疼痛炎性因子表达的影响和临床疗效。方法选取2014年1月~2019年8月于北华大学附属医院神经内科、吉林医药学院附属医院神经内科门诊及住院接受治疗的160例帕金森病慢性疼痛患者,根据Ford法进行疼痛分类和视觉模拟评分法(VAS)评估,随机分为A、B两组,A组给予左旋多巴250 mg/次、4次/d;B组给予左旋多巴500 mg/次、2次/d,联用普瑞巴林胶囊100 mg/次、2次/d,两组治疗均持续2周。评估不同治疗方案对患者各种疼痛的治疗效果,并检测患者体内炎性因子的水平。结果A、B两组治疗后平均VAS评分均降低,且B组与A组比较降低更显著,差异均有统计学意义(P<0.05);治疗后B组比A组骨骼肌疼痛、神经根性疼痛的VAS评分低,差异均有统计学意义(P<0.05);与治疗前比较,治疗后A组原发中枢性疼痛VAS评分差异无统计学意义(P>0.05),B组与治疗前比较差异具有统计学意义(P<0.05)。治疗后B组白细胞介素-8(IL-8)、IL-6和肿瘤坏死因子-α(TNF-α)水平均低于A组,差异具有统计学意义(P<0.05)。结论普瑞巴林参与帕金森病伴慢性疼痛患者体内的炎症反应过程,可有效缓解患者骨骼肌疼痛、神经根性疼痛以及原发中枢性疼痛症状。
Objective To analyze the effect of pregabalin on the expression of inflammatory factors in patients with Parkinson's disease and chronic pain.Methods 160 patients with Parkinson's disease and chronic pain in the Affiliated Hospital of North China University and the Affiliated Hospital of Jilin Medical University were selected between January 2014 and August 2019.The patients were divided into group A and group B according to Ford pain classification and visual analogue scale(VAS)assessment.Group A was given levodopa 250 mg each time and 4 times a day.Group B was given levodopa 500 mg each time and twice a day,plus pregabalin capsules 100 mg each time and twice a day.Both groups were treated for 2 weeks.The pain was assessed and the level of inflammatory factors was tested.Results The scores of VAS in the two groups were reduced after treatment,and the score in group B was significant lower than that in group A(P<0.05).VAS scores of skeletal muscle pain and radicular pain in group B were significant lower than those in group A(P<0.05).There was no significant difference in VAS score of the primary central pain before and after treatment in group A(P>0.05),however there was significant difference in group B(P<0.05).The levels of interleukin-8,interleukin-6 and tumor necrosis factor-αin group B were significantly lower than those in group A(P<0.05).Conclusion Pregabalin may effectively relieve the skeletal muscle pain,radicular pain and primary central pain in patients with Parkinson's disease by regulating inflammatory response.
作者
赵丽丽
田慧
姜立刚
Zhao Lili;Tian Hui;Jiang Ligang(Department of Neurology,the Affiliated Hospital of Jilin Medical University,Jilin 132000,China;The Affiliated Hospital of North China University,Jilin 132000,China)
出处
《国际老年医学杂志》
2020年第5期273-275,279,共4页
International Journal of Geriatrics
基金
吉林省卫生健康委科技创新项目(20172C030)
吉林省中医药管理局科技项目(2017251)。
关键词
帕金森病
疼痛
普瑞巴林
炎性因子
Parkinson's disease
Pain
Pregabalin
Inflammatory factors
