摘要
目的探讨帕金森病(PD)患者外周血促炎症物质与抑郁、焦虑的关系。方法选取本院神经内科收治的80例确诊为PD患者(帕金森组),另选取同期一般资料与帕金森组相匹配的80例健康人群作为健康组。检测两组研究对象外周血白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-ɑ(TNF-ɑ)、干扰素-γ(INF-γ)、血清可溶性白介素2受体(s IL-2R)、超敏C反应蛋白(hs-CRP)的水平,采用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)对两组抑郁焦虑情况进行评价。结果帕金森组IL-1β、IL-6、TNF-ɑ、s IL-2R、hs-CRP水平显著高于健康组,差异均有统计学意义(P<0.05);两组患者的INF-γ水平比较,差异无统计学意义(P>0.05)。帕金森组HAMD、HAMA评分均显著高于健康组(P<0.05)。帕金森患者HAMD、HAMA评分与患者外周血s IL-2R、hs-CRP均呈显著性正相关(P<0.05)。结论PD患者外周血促炎症物质呈高表达状态,外周血s IL-2R、hs-CRP与患者并发抑郁、焦虑具有一定的关系。
Objective To investigate the relationship between peripheral blood and depression and anxiety in patients with Parkinson＇s disease（ PD）. Methods 80 cases of PD patients（ Parkinson group） were selected from the Department of internal medicine of our hospital; 80 cases in the same period whose general information matched with the Parkinson group were recruited as the health group. The peripheral blood interleukin prime beta 1（ IL-1β）,interleukin IL- 6（ IL-6）,tumor necrosis factor- alpha（ TNF-ɑ）,interferon-γ（ INF-γ）,serum soluble interleukin 2 receptor（ s IL- 2R）,super sensitive C reactive protein（ hs-CRP） level were dected in the two groups of subjects. Hamilton Depression Rating Scale（ HAMD） and Hamilton Anxiety Scale（ HAMA） were used to evaluate the depression and anxiety in the two groups. Results The levels of IL- 1 P,IL- 6,TNF alpha,s IL-2R,hs CRP in Parkinson＇s group were significantly higher than that in the healthy group,the difference is statistically significant（ P〈0. 05）; There was no significant difference in INF-γlevel between the two groups（ P〈0. 05）.The scores of HAMD and HAMA in the Parkinson group were significantly higher than those in the healthy group（ P〉0. 05）. The HAMD and HAMA scores of patients with Parkinson were positively correlated with hs-CRP and s IL-2R in peripheral blood（ P〈0. 05） HRSD. Conclusion The peripheral blood promoting inflammatory mediators of PD patients was highly expressed,and the peripheral blood s IL- 2R and hs-CRP were related to the patients with depression and anxiety.
出处
《国际精神病学杂志》
2015年第6期60-63,共4页
Journal Of International Psychiatry
关键词
帕金森病
促炎症物质
抑郁
焦虑
Parkinson＇s disease
Substance
Depression
Anxiety
