摘要
目的探讨宫颈癌患者的人乳头瘤病毒感染型别与宫颈临床病理之间关系。方法回顾性分析2015年1月至2015年12月在江西省妇幼保健院因IB-IIA宫颈癌行根治性宫颈癌手术141例,术前采用导流杂交基因芯片技术对HPV感染进行基因诊断和分型,比较HPV型别在年龄、脉管见癌栓、肌层浸润、临床分期、病理类型和淋巴结转移上的差异。结果宫颈癌中单一HPV感染为主。宫颈癌组织中总HPV感染率为89.4%(126/141),单一感染率为77.3%(109/141),多重感染率为12.1%(17/141),主要感染型别依次为HPV l6、18、52和58。无论是单一感染还是多重感染,均以含HPV16为主要的感染型别。HPV多重感染与单一感染、无HPV感染的比例在病理分级方面存在差异(P<0.05),在年龄、脉管见癌栓、肌层浸润、临床分期、病理类型和淋巴结转移上无差异。16、18型感染与其他型别感染、无HPV感染的比例在病理分级方面存在差异(P<0.05),在年龄、脉管见癌栓、肌层浸润、临床分期、病理类型和淋巴结转移上无差异。结论HPV多重感染及HPV16和18型感染与宫颈癌患者病理分级有关,与年龄、脉管见癌栓、肌层浸润、临床分期、病理类型和淋巴结转移上无差异,可能是独立的致癌因子。
Objective To investigate the relationship between the type of human papillomavirus infection and clinical pathology of cervical cancer.Methods 141 patients with IB-IIA cervical cancer underwent radical cervical cancer surgery from January 2015 to December 2015 in Jiangxi maternal and child health hospital,before operation,the HPV infection was diagnosed and classified by gene chip technique,and the differences of HPV types in age,vascular tumor thrombus,muscle invasion,clinical stage,pathological type and lymph node metastasis were compared.Results Single HPV infection was predominant in cervical cancer.The total infection rate of HPV was 89.4%(126/141),the single infection rate was 77.3%(109/141),and the multiple infection rate was 12.1%(17/141).The main infection types were HPV 16,18,52 and 58 respectively.HPV16 is the major type of infection in both single and multiple infections.The ratio of HPV multiple infection to single infection and no HPV infection had difference in pathological grade(P<0.05),but no difference in age,Vascular Cancer Embolus,muscular invasion,clinical stage,pathological type and lymph node metastasis.HPV16,18 infection and other types of infection,HPV infection in the proportion of the pathological grade there was difference(P<0.05),but no difference in age,Vascular Cancer Emboli,muscle infiltration,clinical stage,pathological type and lymph node metastasis.Conclusion Multiple HPV infections and HPV16 and hpv18 infection are associated with the pathological grade of cervical cancer patients,but not with age,vascular tumor thrombus,myometrial invasion,clinical stage,pathological type and lymph node metastasis,could be an independent carcinogen.
作者
敖梅红
郑涵
李明梅
李隆玉
AO Meihong;ZHENG Han;LI Mingmei(Department of Gyneclogical Oncology,Maternal and Child Hospital of Jiangxi Province,Nanchang 330006,China)
出处
《江西医药》
CAS
2020年第9期1180-1182,1227,共4页
Jiangxi Medical Journal
基金
江西省科技厅自然科学基金,编号2015ZBAB205015
江西省科技计划社会发展领域项目,编号20133BBG70049。
关键词
宫颈癌
人乳头瘤病毒
基因亚型
临床病理特性
Cervical cancer
Human Papillomavirus
Gene subtype
Clinicopathologic features
