摘要
目的探讨柴枳平肝汤联合多潘立酮治疗肝胃不和证功能性消化不良(FD)疗效及其作用机制分析。方法选取2017年6月至2018年9月北部战区总医院诊断为肝胃不和证功能性消化不良患者90例,按照随机数字法分为观察组和对照组,每组45例。对照组患者给予多潘立酮片治疗,观察组在对照组治疗基础上给予柴枳平肝汤,两组患者连续治疗28 d并对疗效进行评价。比较两组中医症候主症、次症及症状总积分、胃动素(MTL)、生长抑素(SS)及胃排空率,记录患者临床疗效、不良反应及3个月随访期间复发率,并分析症状总积分、MTL、SS及胃排空率之间的相关性。结果治疗后,观察组和对照组总有效率分别为88.89%和71.11%,差异有统计学意义(P<0.05);观察组和对照组治疗期间不良反应发生率分别为2.22%和4.44%,差异无统计学意义(P>0.05);随访期间,观察组和对照组复发率分别为13.33%和40.00%,差异有统计学意义(P<0.05)。治疗前,两组主症评分、次症评分、症状总积分、MTL、SS和胃排空率比较差异无统计学意义(P>0.05);治疗后,两组各症状积分、胃排空率均低于治疗前(P<0.05),观察组下降更为明显,两组间差异均有统计学意义(P<0.05);治疗后,MTL、SS在观察组中低于治疗前(P<0.05),而对照组治疗前后差异无统计学意义(P>0.05)。相关性分析显示,MTL分别与SS和症状总积分呈明显负相关(r=-12.356,P=0.000;r=-6.215,P=0.032),胃排空率分别与SS和症状总积分呈明显负相关(r=-11.458,P=0.000;r=-7.215,P=0.002),SS与症状总积分呈正相关(r=8.458,P<0.01),MTL与胃排空率二者呈明显正相关关系(r=15.254,P=0.000)。结论柴枳平肝汤联合多潘立酮可有效改善FD患者临床症状,疗效确切,安全性好,治疗机制可能与柴枳平肝汤改善胃肠激素MTL、SS水平有关。
Objective To explore the efficacy and mechanism of Chaiqi Pinggan Decoction combined with domperidone in the treatment of functional dyspepsia(FD)of liver and stomach disharmony.Methods Total 90 cases of patients with liver and stomach functional dyspepsia who were admitted to our hospital for digestive medicine and outpatient clinic from June 2017 to September 2018 were selected as subjects.According to the random number,they were divided into observation group and control group,45 cases in each group.Patients in the control group were treated with domperidone tablets,and the observation group was given Chaiqin Pinggan Decoction on the basis of the control group.Two groups of patients were treated continuously for 28 days and the efficacy was evaluated.Compare the two groups of TCM symptom main symptoms,secondary disease and symptom total score and motilin(MTL),somatostatin(SS),gastric emptying rate.The patient’s clinical efficacy,adverse reactions,and recurrence rate during the 3-month follow-up were recorded,and the correlation between total symptom scores,MTL,SS,and gastric emptying rate was analyzed.Results After treatment,the total effective rate of the observation group and the control group were 88.89%and 71.11%,respectively,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group and the control group were 2.22%and 4.44%,respectively,and the difference was not statistically significant(P>0.05).During the follow-up period,the recurrence rates of the observation group and the control group were 13.33%and 40.00%,respectively,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the scores of main symptoms,secondary syndrome,total symptom scores,MTL,SS and gastric emptying rate between the two groups(P>0.05).After treatment,the symptom scores and gastric emptying rate of the two groups were lower than those before treatment(P<0.05).The decrease of the observation group was more obvious.The
作者
邹蕾
黄志远
杨桥
金红旭
ZOU Lei;HUANG Zhi-yuan;YANG Qiao;JIN Hong-xu(Department of emergency medicine,Northern Theater General Hospital Shenyang)
出处
《现代消化及介入诊疗》
2020年第8期1031-1036,共6页
Modern Interventional Diagnosis and Treatment in Gastroenterology
关键词
功能性消化不良
肝胃不和证
胃动素
生长抑素
柴枳平肝汤
Functional dyspepsia
Liver and stomach disharmony
Motilin
somatostatin
Chaiqin Pinggan Decoction
