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FibroScan、APRI和FIB-4监测慢性乙肝患者抗病毒治疗效果 被引量:4

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摘要 目的应用瞬时弹性波扫描(FibroScan)、APRI和FIB-4观察具有显著肝组织学改变(SLHC)的慢性乙型肝炎(CHB)患者的抗病毒治疗效果。方法纳入2016年1月至2017年12月就诊的具有SLHC特征的CHB患者80例,应用恩替卡韦(ETV)治疗6个月后,用FibroScan、APRI和FIB-4观察治疗效果。结果经治疗后,轻度纤维化、显著纤维化和肝硬化患者及HbeAg阳性患者的的肝硬度值(LSM)较治疗前都出现下降,尤其是显著纤维化和肝硬化的变化有极其显著差异(P<0.001)。轻度纤维化、显著纤维化和肝硬化患者及HbeAg阳性患者的APRI在治疗后都出现了极其显著的降低(P<0.001),治疗后的FIB-4的数值也都出现下降,具有临床意义。结论FibroScan、APRI和FIB-4可用于观察慢性肝炎治疗的效果。
出处 《现代消化及介入诊疗》 2020年第7期948-950,共3页 Modern Interventional Diagnosis and Treatment in Gastroenterology
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