摘要
目的探讨影响普通人群肝脏受控衰减参数的相关因素。方法使用FibroScan○R-520诊断仪检测208例健康体检者肝脏受控衰减参数(CAP值),同时获取受试者的主要生化指标和性别、年龄、体质量指数、腰高比、腰臀比,对其进行多元线性回归分析和偏最小二乘回归分析,建立回归方程。结果多元线性回归分析显示,CAP值与体质量指数、腰臀比和年龄呈显著性相关,其标准回归系数分别为:体质量指数,β=0.2538,P=0.0007;腰臀比,β=0.1781,P=0.0158;年龄,β=0.1935,P=0.0022;通过多元回归分析和偏最小二乘回归建立的模型分别为:CAP=-137.70+9.40×甘油三脂+5.40×体质量指数+176.34×腰臀比+1.60×年龄,改良的CAP=-135.23+11.57×甘油三脂+4.82×体质量指数+212.81×腰臀比+1.12×年龄。结论普通人群CAP正常值范围受体质量指数、腰臀比和年龄的影响,改良的回归模型能更好地反映肝脏CAP值。
Objective To explore the related factors of controlled attenuation parameter （CAP） of liver ob-tained by FibroScan examination in healthy individuals. Methods The CAP was obtained by FibroScan in 208 healthy persons,and the main biochemical indexes,gender,age,body mass index （BMI）,waist-hip ratio （WHR） and waist-height ratio were collected at the same time,and the relationship between CAP value and these common indi-cators was analyzed. Results Multiple linear regression analysis showed that CAP value was significantly correlated with BMI,WHR and age （for BMI,β=0.280,P=0.0002;for WHR,β=0.206,P=0.0059;for age,β=0.192,P=0.0022）;And the regression equation established after multiple linear regression analysis and partial least squares regression were CAP=-137.70＋9.40＊TG＋5.40＊BMI＋176.34＊WHR＋1.60＊age and the adjusted CAP=-92.11＋10.67＊TG- 10.25＊HDL＋4.45＊BMI＋196.25＊WHR＋1.03＊age. Conclusions The range of CAP value is affected by BMI,WHR,and age in the general population,the adjusted regression equation is more better to predict the CAP value of the liver.
出处
《实用肝脏病杂志》
CAS
2014年第3期291-294,共4页
Journal of Practical Hepatology
基金
国家重点基础研究发展计划(973计划)项目(2012CB517501)
上海市科委创新行动计划(10411956300)
中国肝炎防治基金会王宝恩肝纤维化研究基金资助项目(XJS20120501)
上海交通大学医学院附属新华医院院长基金项目(12QYJ05)
