摘要
目的:探讨冠心病(CHD)患者经皮冠脉介入术(PCI)前后患者血清成纤维细胞生长因子21(FGF-21)、血管内皮细胞生长因子(VEGF)、结缔组织生长因子(GTGF)的变化与心功能变化的关系。方法:选取我院2017年9月—2018年10月实施PCI手术治疗的CHD患者77例(CHD组)、健康体检人群77例(对照组),采用ELISA检测两组的血清FGF-21、VEGF、GTGF水平,采用超声心动图检测CHD组患者术前、术后6个月的左室射血分数(LVEF%)、左室舒张末期内经(LVEDd)、左室短轴缩短率(LVFS),并进行相关性分析。结果:CHD组患者在PCI术前、术后1周的血清FGF-21、VEGF及GTGF水平均显著的高于对照组(P<0.05);CHD组患者在PCI术后1周,血清FGF-21、GTGF水平较术前显著的降低(P<0.05),VEGF水平较术前显著升高(P<0.05);CHD组患者在PCI术前、术后1周的LVEF%、LVFS%水平均显著的低于对照组(P<0.05),LVEDd测定值高于对照组(P<0.05);CHD组患者在PCI术后6个月,LVEF%、LVFS%水平较术前显著的升高(P<0.05),LVEDd较术前显著的降低(P<0.05);CHD组患者在PCI术前血清FGF-21、GTGF水平与LVEF%、LVFS%水平均呈显著的负相关关系(P<0.05),血清FGF-21、GTGF水平与LVEDd测定值呈显著的正相关关系(P<0.05)。结论:CHD患者PCI术前及术后的血清FGF-21、GTGF水平较健康人群显著升高,VEGF在PCI术后升高,PCI术前血清FGF-21、GTGF水平升高与患者术后心功能恢复有关。
Objective:To investigate the relationship between the changes of serum fibroblast growth factor 21(FGF-21),vascular endothelial growth factor(VEGF),connective tissue growth factor(GTGF)and cardiac function in patients with coronary heart disease(CHD)before and after percutaneous coronary intervention(PCI).Methods:77 CHD patients who underwent PCI(CHD group)and 77 healthy people(control group)from September 2017 to October 2018 were selected.Serum levels of FGF-21,VEGF and GTGF were measured by ELISA.Left ventricular ejection fraction(LVEF%),left ventricular end diastolic diameter(LVEDd)and left ventricular short axis shortening rate(LVFS)were measured by echocardiography before and 6 months after operation in CHD group,and perform correlation analysis.Results:Serum FGF-21,VEGF and GTGF levels were significantly higher in the CHD group than in the control group before and 1 week after surgery(P<0.05).In the CHD group,1 week after PCI,the level of serum FGF-21 and GTGF was significantly lower than that before surgery(P<0.05),and the level of VEGF was significantly higher than that before surgery(P<0.05).The LVEF%and LVFS%levels of patients in the CHD group were significantly lower than those in the control group before and 1 week after surgery(P<0.05),and the LVEDd values were higher than those in the control group(P<0.05).At 6 months after operation,LVEF%and LVFS%levels were significantly higher than those before surgery(P<0.05),and LVEDd was significantly lower than before surgery(P<0.05).In patients with CHD before surgery,there was a significant negative correlation between GTGF level,serum FGF-21 and LVEF%,LVFS%levels(P<0.05).There was a significant positive correlation between serum FGF-21 and GTGF levels,LVEDd(P<0.05).Conclusion:The levels of serum FGF-21 and GTGF in CHD patients before and after PCI were significantly higher than those in healthy people.The levels of VEGF increased after PCI.The elevated levels of serum FGF-21 and GTGF before PCI were related to the recovery of cardiac function.
作者
郭华
GUO Hua(The Second People’s Hospital of Zhengzhou City,He’nan Province 450000)
出处
《医学理论与实践》
2020年第18期2961-2963,2960,共4页
The Journal of Medical Theory and Practice
关键词
冠心病
经皮冠脉介入术
成纤维细胞生长因子21
血管内皮细胞生长因子
结缔组织生长因子
Coronary heart disease
Percutaneous coronary intervention
Fibroblast growth factor 21
Vascular endothelial growth factor
Connective tissue growth factor
