摘要
目的研究血小板抗体检测评估白血病患儿多次血小板输注的效果。方法分析2015年3月-2018年6月在首都医科大学附属北京同仁医院接收的白血病患儿76例,根据患者输注的单采血小板次数分为三组:A组血小板输注≤3次(23例);B组血小板输注3~6次(28例);C组血小板输注>6次(25例),并选择同时期健康体检者66例。分析研究对象的血小板抗体阳性率、血小板增值指数(CCI)、输注有效率以及非溶血性输血反应(NHTR)发生率。结果健康体检者血小板相关抗体阳性为2例,阳性率为3.03%;白血病患儿中血小板抗体阳性为21例,阳性率为27.63%,白血病患儿的阳性率明显高于健康体检者,差异有统计学意义(P<0.05)。白血病患儿中A组、B组的血小板抗体阳性率分别为13.04%、17.85%,差异无统计学意义(P>0.05),但A组、B组的血小板抗体阳性率明显低于C组的52.00%,差异有统计学意义(P<0.05)。阳性患儿的血小板输注后1 h、24 h的CCI值均明显低于阴性患儿,差异有统计学意义(P<0.05),且输注无效率为80.95%,NHTR发生率为47.62%,均明显高于阴性患儿的20.00%、12.73%,差异有统计学意义(P<0.05)。结论白血病患儿的血小板抗体阳性率明显较高,且随着血小板输注次数的增多,血小板抗体检出率明显提高。
Objective To study the effect of platelet antibody assay on the infusion of multiple blood transfusions in children with leukemia.Methods 76 patients with leukemia received from our hospital from March 2015 to June 2018 were analyzed;according to the number of platelet transfusions infused,patients were divided into three groups:group A platelet transfusion≤3 times(23 cases);group B platelet transfusion was performed 3 to 6 times(28 cases);group C platelet transfusion was>6 times(25 cases),and 66 healthy subjects were selected at the same time.The platelet antibody positive rate and platelet proliferation index [corrected count increment(CCI),infusion efficiency,and incidence of nonhemolytic transfusion reaction(NHTR)]were analyzed.Results Among the 66 healthy subjects,2 were positive for platelet-associated antibodies,and the positive rate was 3.03%.Among the leukemia patients,21 were positive for platelet antibodies,and the positive rate was 27.63 %.The positive rate of leukemia patients was significantly higher than that of healthy subjects(P<0.05).The positive rate of platelet antibody in group A and group B was 13.04% and 17.85%,respectively,which was not statistically significant(P>0.05),but the positive rate of platelet antibody in group A and group B was significantly lower than that in group C(52.00%,P<0.05).The CCI values at 1 h and 24 h after platelet transfusion in positive patients were significantly lower than those in negative patients(P<0.05),and the ineffective rate of infusion was80.95%,and the incidence of NHTR was 47.62%,which was significantly higher than that of negative patients(20.00%,12.73%,P<0.05).Conclusion The positive rate of children with leukemia was significantly higher,and as the number of platelet transfusions increased,the detection rate of platelet antibodies was increase significantly.
作者
赵蕊
李淑萍
李松涛
ZHAO Rui;LI Shu-ping;LI Song-tao(Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)
出处
《热带医学杂志》
CAS
2020年第8期1062-1064,1069,共4页
Journal of Tropical Medicine
