摘要
目的分析反复输血者血小板抗体对血小板输注效果的影响,以便为日后临床提供参考。方法回顾性分析2023年1月至2023年12月焦作市人民医院收入的1216例反复输血患者,对其开展血小板抗体检测,分析抗体呈阳性的患者输注血小板的治疗效果;根据患者的血小板抗体检验结果,将配型为阴性或弱阳性的供者标本归类为相符亚组,而多次配型为阳性的供者标本则归类为不符亚组。对比首次输注后的阳性组和阴性组,以及相符亚组与不符亚组本次输注后的情况,分析1 h和24 h的血小板校正增高计数(CCI)以及血小板回收率(PPR)之间的差异。通过Spearman相关系数模型,总结1 h和24 h的血小板CCI以及PPR与血小板抗体检验、以及交叉配型试验结果之间的相关性。结果相较于阳性组患者,阴性患者CCI、PPR指标及输注效果均明显升高,且血小板输注无效(PTR)发生率降低,差异有统计学意义(P<0.05);相符亚组输注后l h、24 h CCI及PPR水平均高于不符亚组,差异有统计学意义(P<0.05);Spearman相关系数模型分析结果显示,血小板抗体检测结果与CCI、PPR水平呈负相关,交叉配型结果与CCI、PPR水平呈正相关,差异有统计学意义(P<0.05)。结论患者在接受多次输血后,血小板抗体的检测阳性率相对较高,抗体生成直接关系输注血小板疗效。检测血小板抗体和进行交叉配型的结果与患者接受的血小板输注效果密切相关。
Objective To analyze the impact of platelet antibodies on the effectiveness of platelet transfusion in patients undergoing repeated transfusions,aiming to provide reference for future clinical practice.Methods A retrospective analysis was conducted on 1,216 patients who received repeated transfusions at Jiaozuo People's Hospital from January 2023 to December 2023.Platelet antibody tests were performed,and the therapeutic effect of platelet transfusion in antibody-positive patients was analyzed.Based on the results of platelet antibody tests,donor samples with negative or weakly positive antibodies were classified as the matching subgroup,while donor samples with repeatedly positive antibodies were classified as the non-matching subgroup.The post-transfusion outcomes were compared between the antibody-positive and antibody-negative groups,as well as between the matching and non-matching subgroups,by analyzing the differences in corrected count increment(CCI)and percent platelet recovery(PPR)at 1 hour and 24 hours after transfusion.The correlation between platelet CCI and PPR at 1 hour and 24 hours with platelet antibody test results and cross-matching test results was summarized using the Spearman correlation coefficient model.Results Compared to the antibody-positive group,antibody-negative patients showed significantly higher CCI and PPR indicators and better transfusion effectiveness,with a lower incidence of platelet transfusion refractoriness(PTR),with statistically significant differences(P<0.05).The matching subgroup showed higher CCI and PPR levels at 1 hour and 24 hours post-transfusion compared to the non-matching subgroup,with statistically significant differences(P<0.05).Spearman correlation coefficient model analysis showed a negative correlation between platelet antibody test results and CCI/PPR levels,and a positive correlation between cross-matching test results and CCI/PPR levels,with statistically significant differences(P<0.05).Conclusion The detection rate of platelet antibodies is relatively h
作者
郑佳欣
ZHENG Jiaxin(Department of Transfusion,Jiaozuo People's Hospital,Jiaozuo Henan 454001,China)
出处
《临床研究》
2024年第11期92-95,共4页
Clinical Research
关键词
反复输血者
血小板抗体
血小板交叉配型试验
血小板输注效果
repeated transfusions
platelet antibodies
platelet cross-matching test
platelet transfusion effectiveness
