摘要
目的:检测妊娠期高血压疾病患者血浆中血管紧张素原(AGT)、白细胞介素22(IL-22)表达水平,探讨其与患者肾损害(KI)关系。方法:选择2018年3月—2019年5月在本院产科建卡并诊断为妊娠期高血压疾病孕妇120例,其中妊娠期单纯高血压41例、轻度子痫前期39例、重度子痫前期40例;KI 46例、非KI 74例;正常妊娠孕妇40例为对照组。酶联免疫吸附法检测血浆AGT、IL-22、血清肌酐(Cr)水平。Pearson法分析妊娠期高血压疾病肾损害患者血AGT、IL-22与Cr水平相关性。ROC曲线分析AGT、IL-22、Cr对妊娠期高血压疾病肾损害预测价值。结果:与对照组比较,妊娠期高血压疾病患者血浆AGT、IL-22水平升高,且在妊娠期单纯高血压组、轻度子痫前期组、重度子痫前期组依次升高(P均<0.05);KI患者血AGT、IL-22、Cr水平均高于非KI孕妇(P<0.05)。妊娠期高血压疾病KI患者血浆AGT、IL-22与血清Cr水平呈正相关性(r=0.591、0.586,P<0.05);AGT、IL-22、Cr联合检测预测妊娠期高血压疾病肾损害的敏感度为84.8%,特异度为94.6%,曲线下面积为0.936。结论:AGT、IL-22在妊娠期高血压疾病患者中高表达,与患者病情严重程度及并发KI有关,二者联合血清Cr检测对妊娠期高血压疾病肾损害有较高预测价值,有望成为评估妊娠期高血压疾病并发肾损害的分子标志物。
Objective:To detect the expression levels of plasma angiotensinogen(AGT)and interleukin-22(IL-22)of the patients with pregnancy induced hypertension,and to explore the relationships between AGT and IL-22 levels and the renal damage of these patients.Methods:From March 2018 to May 2019,120 pregnant women with pregnancy induced hypertension were selected in the study group,which included group A(41 women with pregnancy induced hypertension),group B(39 women with mild preeclampsia),group C(40 women with severe preeclampsia),group D(46 women with KI),and group E(74 women without KI).And another 40 normal pregnant women were selected in the control group.The levels of plasma AGT and IL-22 and serum creatinine level of all included women were detected by ELISA.Pearson's method was used to analyze the correlations between the levels of plasma AGT and IL-22 and serum creatinine level of women with renal damage caused by pregnancy induced hypertension.And ROC curve was used to analyze the values of AGT and IL-22 levels,and serum creatinine level for predicting renal damage caused by pregnancy induced hypertension.Results:The levels of plasma AGT and IL-22 of women in the study group were significant higher than those of women in the control group,and which of women in group A,group B,and group C had increased in turn(P<0.05).The levels of plasma AGT and IL-22,and serum creatinine level of women in group D were significant higher than those of women in group E(P<0.05).There was a positive correlation between the levels of AGT and IL-22 of women and their serum creatinine level in group D(r=0.591,0.586,P<0.05).The sensitivity,the specificity,and area under the curve of the combination of the levels of AGT,IL-22 and creatinine for predicting renal damage of women with pregnancy induced hypertension were 84.8%,94.6%and 0.936,respectively.Conclusion:The expressions of AGT and IL-22 of women with pregnancy induced hypertension decrease,which are related to the severity of the disease and the complication of KI.The combination o
作者
刘晓玲
张鹏
刘吉红
刘红梅
LIU Xiaoling;ZHANG Peng;LIU Jihong;LIU Hongmei(Qingdao Women and Children's Hospital, Shandong province, 266011)
出处
《中国计划生育学杂志》
2020年第8期1312-1315,1320,共5页
Chinese Journal of Family Planning
