摘要
斑秃是皮肤科常见病,为突然发生的非瘢痕性炎症性局限性脱发,一般多根据年龄、病程、脱发严重程度等选择治疗方案,传统的治疗方法如局部与系统使用糖皮质激素、局部免疫、米诺地尔、免疫抑制剂等,因存在各种潜在副作用、对顽固性斑秃治疗无效以及斑秃治疗后高复发率等问题而不能完全满足斑秃治疗需要。随着斑秃研究的进展,近年来有多种新疗法被发现对治疗斑秃有效,如Janus激酶抑制剂、富血小板血浆疗法、308nm准分子光/激光、点阵激光、磷酸二酯酶-4抑制剂等。目前有关新疗法研究不多,除以托法替尼为代表的Janus激酶抑制剂研究相对较多以外,其余治疗方法开展的研究较少,现将近年来的新疗法进行综述,以期为临床提供参考。
Alopecia areata is a dermatological common disease for non-scarring inflammatory localized hair loss. Generally, treatment options are selected based on age, course of disease, and severity of hair loss. Traditional treatment methods, such as local and systemic use of glucocorticoids, local immunity, minoxidil, immunosuppressant,etc, can not fully meet the needs of alopecia areata treatment due to various potential side effects, ineffective treatment of intractable alopecia areata and high recurrence rate after alopecia areata treatment. With the development research of alopecia areata, many new therapies have been found to be effective in recent years, such as Janus kinase inhibitor, the therapy of platelet rich plasma, 308 nm excimer light/laser, fractional laser, phosphodiesterase-4 inhibitor, etc. At present, there are few studies on new therapies, except for the Janus kinase inhibitor research represented by to fetinib, other treatments is less to research. It is a review of the progress of new therapies in recent years to provide clinical references.
作者
谭红梅
郭芸
张佩莲
TAN Hong-mei;GUO Yun;ZHANG Pei-lian(Department of Dermatology,the Second Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650101;Department of Dermatology,the First Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming,Yunnan 650021)
出处
《皮肤病与性病》
2020年第4期493-496,共4页
Dermatology and Venereology
关键词
斑秃
新疗法
进展
Alopecia Areata
New Treatment
Advance
