摘要
目的:观察犀角地黄汤联合甲氨蝶呤治疗表层巩膜炎的临床疗效及对房水炎症因子水平的影响。方法:将表层巩膜炎患者104例随机分为2组,对照组52例(52眼)在基础治疗的基础上口服甲氨喋呤片,观察组52例(52眼)在对照组的基础上加服犀角地黄汤;观察2组患者临床疗效、眼压及不良反应,治疗前后房水白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)含量,随访1年记录复发率。结果:总有效率观察组为92.31%,对照组为73.08%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者房水TNF-α、IL-1β及IL-6含量均较治疗前下降(P<0.05),且观察组上述各项指标均明显低于对照组(P<0.05)。治疗后,观察组患者眼压明显低于对照组,差异有统计学意义(P<0.05)。不良反应发生率观察组为5.77%,对照组为7.69%,2组比较,差异无统计学意义(P>0.05)。随访1年,复发率观察组为19.23%,对照组为38.46%,2组比较,差异有统计学意义(P<0.05)。结论:犀角地黄汤联合甲氨蝶呤治疗表层巩膜炎疗效显著,可显著改善患者房水炎症因子水平,降低复发率。
Objective:To observe the clinical effect of Xijiao Dihuang tang combined with methotrexate for episcleritis and its effect on levels of inflammatory factors in aqueous humor.Methods:A total of 104 cases of patients with episcleritis were randomly divided into two groups,52 cases in each group.The control group was given oral administration of methotrexate tablets based on basic treatment,and the observation group was additionally treated with Xijiao Dihuang tang based on the treatment of the control group.The clinical effect,intraocular pressure,adverse reactions as well as the levels of inflammatory factors such as interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in aqueous humor before and after treatment were observed in the two groups.The recurrence rate was recorded during one-year follow-up.Results:The total effective rate was 92.31% in the observation group and 73.08% in the control group,the difference being significant(P<0.05).After treatment,the contents of TNF-α,IL-1 and IL-6 in aqueous humor in the two groups were all decreased when compared with those before treatment(P<0.05),and each index in the observation group was significantly lower than that in the control group(P<0.05).After treatment,the intraocular pressure in the observation group was significantly lower than that in the control group,the difference being significant(P<0.05).The incidence of adverse reactions was 5.77% in the observation group and 7.69% in the control group,there being no significance in the difference(P>0.05).During one-year follow-up,the recurrence rate was 19.23% in the observation group and 38.46% in the control group,the difference being significant(P<0.05).Conclusion:Xijiao Dihuang tang combined with methotrexate has significant clinical effect,which can effectively reduce the levels of inflammatory factors in aqueous humor and the recurrence rate.
作者
钱蕾
余亚波
陈彦
QIAN Lei;YU Yabo;CHEN Yan
出处
《新中医》
CAS
2020年第16期41-43,共3页
New Chinese Medicine
关键词
表层巩膜炎
中西医结合疗法
甲氨蝶呤
犀角地黄汤
炎症因子
Episcleritis
Integrated Chinese and western medicine therapy
Methotrexate
Xijiao Dihuang tang
Inflammatory factors
