摘要
目的:分析钙敏感受体(CaSR)、三磷酸腺苷结合盒转运体G2(ABCG2)与三阴性乳腺癌(TNBC)的侵袭、恶性程度及淋巴结转移的相关性,探讨CaSR和ABCG2在TNBC组织中的阳性表达率,评价其在TNBC及临床预后的诊断价值。方法:收集2018年3月-2019年6月本院普外科(50例)和乳腺外科(150例)收治的经病理诊断为乳腺癌的200例患者作为研究对象,其中50例(25.00%)TNBC患者作为研究组,150例(75.00%)非三阴性乳腺癌(non-TNBC)患者作为对照组,采用免疫组化染色SP法检测两组癌组织中CaSR、ABCG2的阳性表达率。结果:研究组CaSR、ABCG2阳性表达率明显高于对照组(χ^2=6.59、6.06,P<0.05);研究组CaSR、ABCG2阳性表达与年龄、绝经情况、肿瘤大小、病理学分级及脉管癌栓均无显著相关性(P>0.05),与转移、病理类型及TNM分期均存在显著相关性(P<0.05)。Kaplan-Meier生存分析结果显示,在TNBC患者癌组织中CaSR、ABCG2阳性表达者中位生存期(OS)和中位无瘤生存期(DFS)低于阴性表达者(P<0.05)。结论:CaSR和ABCG2表达与TMBC的侵袭、恶性程度及淋巴结转移均存在相关性;CaSR和ABCG2可能对TNBC患者的临床预后具有预测价值。
Objective:To analyze the correlation between calcium sensing receptor(CaSR),atp binding box transporter G2(ABCG2)and triple negative breast cancer(TNBC)invasion,malignancy and lymph node metastasis,to investigate the positive expression rate of CaSR and ABCG2 in TNBC tissues,and to evaluate the diagnostic value of CaSR and ABCG2 in TNBC and clinical prognosis.Method:From March 2018 to June 2019,200 cases of breast cancer patients by pathological diagnosis in department of general surgery(50 cases)and breast surgery(150 cases)were collected as the research objects,50 cases(25.00%)patients with TNBC were selected as the research group,150 cases(75.00%)of non-three negative breast cancer(non-TNBC)patients were selected as the control group,the immunohistochemical staining SP method were used to detect CaSR and ABCG2 positive expression rate in two groups of patients’carcinoma tissue.Result:The positive expression rates of CaSR and ABCG2 in the study group were significantly higher than those in the control group(χ~2=6.59,6.06,P<0.05).The positive expressions of CaSR and ABCG2 in the study group were not significantly correlated with patients’age,menopausal status,tumor size,pathological grade and vascular cancer thrombus(P>0.05),but were significantly correlated with metastasis,pathological type and TNM stage(P<0.05).The results of Kaplan-Meier survival analysis showed that median survival(OS)and median tumor-free survival(DFS)in CaSR,ABCG2 positive expression in cancer tissues of TNBC patients were lower than those of negative expression(P<0.05).Conclusion:CaSR and ABCG2 are correlated with TMBC invasion,malignancy and lymph node metastasis.CaSR and ABCG2 may have predictive value for the clinical prognosis of TNBC patients.
作者
肖宏卫
许晓峰
谭丽珊
林泉
XIAO Hongwei;XU Xiaofeng;TAN Lishan;LIN Quan(Shaoguan First People’s Hospital,Shaoguan 512000,China;不详)
出处
《中国医学创新》
CAS
2020年第21期18-22,共5页
Medical Innovation of China
基金
韶关市科技计划(医学)基金(韶科(卫)SY2015-01)。
关键词
钙敏感受体
三磷酸腺苷结合盒转运体G2
三阴性乳腺癌
淋巴结转移
Calcium sensitive receptor
Atp binding box transporter G2
Triple negative breast cancer
Lymph node metastasis
