摘要
目的调查分析上海崇明地区2015至2018年成人体检人群高尿酸血症(HUA)患病率,分析其与血尿素(UN)、肌酐(CRE)和血脂的相关性,为本地区防治高尿酸引起的相关慢性病提供流行病学资料。方法利用实验室信息管理系统(LIS)调取2015至2018年体检中心人群血清尿酸(SUA)、UN、CRE和三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等,共获得标本总数67639例,其中男41596例,女26043例。对数据进行统计分析,提炼本地区成年人群HUA患病率流行病学特征。结果本地区HUA整体患病率为10.34%,其中男性患病率显著高于女性(13.42%vs.5.42%,χ2=1105.8,P<0.001)。HUA人群UN、CRE、Tch、TG、LDL-C显著高于尿酸正常组,HDL-C在HUA组低于尿酸正常组(P<0.05)。不同年龄段人群HUA患病率有显著性差异,<50岁HUA患病率表现相对稳定,≥50岁,不论男女,高尿酸血症的患病率均呈现持续升高的趋势(P<0.01)。HUA与TG、TCH、LDL-C、UN、CRE等呈正相关,HUA与HDL-C等呈负相关(P<0.01)。2015至2018年,总体上男性、女性HUA患病率均呈现逐年升高的趋势。多因素Logistic回归分析显示,男性患者、UN、CRE、TG、LDL-C等为HUA的风险因素,女性、HDL-C等因素为保护因素。结论2015至2018年,无论男性还是女性,均表现出HUA患病率呈逐年升高态势,说明控制本地区HUA发病率刻不容缓,应该引起足够重视。
Objective To investigate the prevalence of hyperuricemia(HUA)in adult physical examination population in Chongming distict of Shanghai from 2015 to 2018,and to analyze its correlation with blood urea(UN),creatinine(CRE)and blood lipids,so as to provide epidemiological data for the prevention and treatment of chronic diseases caused by hyperuricemia in this area.Methods The data of serum uric acid(SUA),UN,CRE,triglyceride(TG),cholesterol(Tch),high density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)in adult physical examination population in Chongming district of Shanghai from 2015 to 2018 were collected by using the laboratory information management system(LIS)of our hospital.A total of 67,639 samples were obtained,including 41,596 males and 26,043 females.And the data were statistically analyzed to extract the epidemiological characteristics of HUA prevalence in adult population in this area.Results The overall prevalence rate of HUA in this area was 10.34%,in which the prevalence rate in males was significantly higher than that in females(13.42%vs.5.42%,P<0.01).The levels of UN,CRE,Tch,TG and LDL-C in HUA group were significantly higher than those in normal uric acid group,however,the HDL-C levels in HUA group were significantly lower than those in normal uric acid group(P<0.05).There was a significant difference in the prevalence rate of HUA among different age groups.The prevalence rate of HUA was relatively stable in the patients under 50 years of age,however,in the patients above 50 years of age,the prevalence rate of hyperuricemia was increased continuously in both males and females.In addition HUA was positively correlated with TG,TCH,LDL-C,UN and CRE,however,which was negatively correlated with HDL-C.During 2015~2018,the prevalence rate of HUA was increased year by year in both males and females.Multivariate Logistic regression analysis showed that UN,CRE,TG and LDL-C were risk factors for HUAin male patients,but HDL-C was protective factors for HUA in female patients.Conc
作者
胡道军
王俊
张莉
郁淼
秦兵
沈宝岩
HU Daojun;WANG Jun;ZHANG Li(Department of Clinical Laboratory,Xinhua Hospital Affiliated to Medical College of Shanghai Jiaotong University,Shanghai 202150,China)
出处
《河北医药》
CAS
2020年第17期2684-2687,2691,共5页
Hebei Medical Journal
基金
上海市崇明区科委研究课题(编号:CKW2018-11)
上海交通大学医学院附属新华医院崇明分院优秀青年医学人才培养计划。
关键词
高尿酸血症
患病率
肌酐
尿素
血脂升高
hyperuricemia
prevalence
creatinine
urea
hyperlipidemia
