摘要
目的探究还原性谷胱甘肽治疗中毒性急性肾衰竭的价值。方法 50例中毒性急性肾衰竭患者,按照随机数字表法分为研究组和对照组,各25例。对照组患者给予常规治疗,研究组患者在常规治疗基础上给予还原型谷胱甘肽治疗。比较两组治疗效果;少尿期、多尿期持续时间以及血肌酐、尿渗透压恢复时间;内生肌酐清除率;尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)水平。结果研究组患者的治疗有效率96.00%高于对照组的68.00%,差异有统计学意义(P<0.05)。研究组少尿期持续时间为(8.62±3.25)d,多尿期持续时间为(23.56±3.16)d,血肌酐恢复时间为(25.32±2.67)d,尿渗透压恢复时间为(11.89±2.41)d,均短于对照组的(14.32±2.78)、(28.36±2.56)、(29.87±3.76)、(22.53±2.78)d,差异有统计学意义(P<0.05)。治疗后,研究组内生肌酐清除率为(87.34±23.56)ml/(min·1.73 m^2),高于对照组的(61.38±21.57)ml/(min·1.73 m^2),差异有统计学意义(P<0.05)。治疗后,研究组尿NAG为(21.79±7.94)U/L,低于对照组的(35.89±12.32)U/L,差异有统计学意义(P<0.05)。结论中毒性急性肾衰竭患者在常规治疗基础上行还原型谷胱甘肽治疗,治疗效果较为显著,能有效改善患者的相关指标,值得临床推广应用。
Objective To investigate the value of reduced glutathione in the treatment of toxic acute renal failure.Methods A total of 50 patients with toxic acute renal failure were divided into research group and control group according to random numerical table,with 25 cases in each group.The control group received conventional therapy,and the research group received reduced glutathione on the basis of conventional therapy.The therapeutic effect,duration of oliguria and polyuria,recovery time of serum creatinine and urine osmotic pressure,endogenous creatinine clearance,urinary N-acetyl-β-D-glucosaminidase(NAG)were compared between the two groups.Results The effective rate of treatment 96.00%of the research group was higher than that of the control group 68.00%,and the difference was statistically significant(P<0.05).The duration of oliguria(8.62±3.25)d,duration of polyuria(23.56±3.16)d,recovery time of serum creatinine(25.32±2.67)d and recovery time of urine osmotic pressure(11.89±2.41)d of the research group was shorter than that of the control group(14.32±2.78),(28.36±2.56),(29.87±3.76)and(22.53±2.78)d,and the difference was statistically significant(P<0.05).After treatment,endogenous creatinine clearance rate(87.34±23.56)ml/(min·1.73 m2)of the research group was higher than that of the control group(61.38±21.57)ml/(min·1.73 m2),and the difference was statistically significant(P<0.05).After treatment,urinary NAG of the research group was(21.79±7.94)U/L,which was lower than that of the control group(35.89±12.32)U/L,and the difference was statistically significant(P<0.05).Conclusion Application of reduced glutathione on the basis of conventional therapy shows remarkable therapeutic effect for patients with toxic acute renal failure,which can effectively improve the relevant indicators of the patient.This treatment method is worthy of clinical promotion and application.
作者
李伏醒
LI Fu-xing(Department of Nephrology,Dandong Central Hospital,Dandong 118000,China)
出处
《中国现代药物应用》
2020年第17期122-124,共3页
Chinese Journal of Modern Drug Application
