摘要
目的观察临床因素和放疗剂量学因素对非小细胞肺癌患者发生急性放射性食管炎的影响。方法选取2018年7月~2019年7月聊城市中医医院接受三维适形放疗的非小细胞肺癌患者中KPS评分≥70分,预计生存时间≥3个月的93例患者。通过计划系统剂量体积直方图获得患者V10、V20、V30、V40、V50、平均剂量、处方剂量等参数,评估患者急性放射性食管炎发生情况。对比发生2级以上放射性食管炎患者与未发生患者的一般临床资料和剂量学资料,分析发生急性放射性食管炎的影响因素。结果93例患者中,2级以上放射性食管炎42例,发生率为45.16%。logistic多因素回归分析结果显示同步化疗、合并糖尿病、食管平均剂量是影响2级以上急性放射性食管炎发生的独立危险因素。结论制订放疗计划时,应充分了解患者的化疗史、合并疾病,综合考虑剂量学因素,降低急性放射性食管炎的发生。
Objective To observe the influence of clinical factors and radiation dosimetry on the acute radiation esophagitis in patients with non-small cell lung cancer.Methods From July 2018 to July 2019,93 patients with non-small cell lung cancer were selected as the study object.Their KPS score≥70 and expected survival time≥3 months.All patients received three-dimensional conformal radiotherapy,and parameters such as V10,V20,V30,V40,average dose and prescription dose were obtained by dose volume histogram.To evaluation the incidence of acute radiation esophagitis.To compare the general clinical data and radiation dose of patients with or without grade 2 acute radiation esophagitis.To analyze the influencing factors of acute radiation esophagitis.Results Among the 93 patients,42 cases had acute radiation esophagitis of grade 2 or above,the incidence was 45.16%.Logistic regression analysis showed that synchronous chemotherapy,diabetes mellitus,esophageal average dose were independent risk factors of acute radiation esophagitis above grade 2.Conclusion In order to reduce the incidence of acute radiation esophagitis,when making the radiotherapy plan,we should fully consider the synchronous chemotherapy history,the combined diseases of patients and the proper dosimetry.
作者
刘玲
周青
孙长侠
Liu Ling;Zhou Qing;Sun Changxia(Department of Oncology,Traditional Chinese Medicine Hospital of Liaocheng,Liaocheng 252000,China)
出处
《中华保健医学杂志》
2020年第4期374-376,共3页
Chinese Journal of Health Care and Medicine
基金
山东省中医药科技发展计划项目(2019—0882)。
关键词
放射性食管炎
放疗
同步化疗
糖尿病
Radiation esophagitis
Radiotherapy
Synchronous chemotherapy
Diabetes mellitus
