摘要
目的:观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)及其合并慢性阻塞性肺疾病(COPD)患者血清炎性因子白细胞介素-17(IL-17)水平的变化。方法:选取OSAHS患者57例、OSAHS合并COPD患者22例及健康体检者23例为研究对象。多导睡眠图(PSG)监测,记录3组睡眠呼吸指标水平,并采用酶联免疫吸附法(ELISA)检测血清IL-17水平。分析IL-17与OSAHS及合并COPD的相关性。结果:OSAHS组、OSAHS合并COPD组血清IL-17水平均高于对照组,且OSAHS合并COPD组高于OSAHS组(P<0.05)。OSAHS合并COPD患者血清IL-17水平与低通气指数(AHI)、最低血氧饱和度(LSaO2)均无相关性(P>0.05)。结论:OSAHS可能是一种与炎症相关的疾病,其炎症过程可能促进COPD的发生。
Objective:To investigate the changes of serum inflammatory factor interleukin-17(IL-17)in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)and chronic obstructive pulmonary disease(COPD).Methods:57 cases of OSAHS patients,22 cases of OSAHS patients with COPD and 23 cases of healthy people were selected.We used PSG polysomnography to record the sleep respiratory index levels of the three groups,and used enzyme-linked immunosorbent assay(ELISA)to detect the level of serum IL-17.We analyzed the correlation of IL-17 with OSAHS and COPD.Results:In OSAHS group and OSAHS combined with COPD group,the serum IL-17 level was higher than that of the control group,and OSAHS combined with COPD group was higher than that of OSAHS group(P<0.05).In OSAHS combined with COPD patients,the level of serum IL-17 had no correlation with AHI and LSaO2(P<0.05).Conclusion:OSAHS may be an inflammation related disease,and its inflammatory process may promote the occurrence of COPD.
作者
郑梦凝
张璐
袁国航
路苹
欧阳章宏
吴竞婧
Zheng Mengning;Zhang Lu;Yuan Guohang;Lu Pin;Ouyang Zhanghong;Wu Jingjing(Department of Respiratory and Critical Care Medicine,the People's Hospital of Guizhou Province,Key Laboratory of Diagnosis and Treatment of Pulmonary Immune Diseases of National Health Commission1,Guizhou Guiyang 550002;The First People's Hospital of Zunyi(The Third Affiliated Hospital of Zunyi Medical University)2,Guizhou Zunyi 563000)
出处
《中国社区医师》
2020年第25期109-110,共2页
Chinese Community Doctors
