摘要
目的分析小剂量的糖皮质激素类药物辅助治疗小儿支原体肺炎对患儿发热、咳嗽、咽部充血症状的影响。方法选择2018年1月—2019年6月本院收治的150例支原体肺炎患儿作为研究对象,随机分为对照组和实验组两组,每组各75例。对照组采纳阿奇霉素治疗,实验组在对照组基础上予以小剂量地塞米松磷酸钠治疗。对比两组临床疗效、临床症状消失时间、血清炎症因子指标、不良反应发生情况。结果实验组临床总有效率(97.33%)明显比对照组(81.33%)高,实验组肺部啰音、发热、咳嗽、咽部充血症状消失时间[(5.06±0.62)d、(1.52±0.11)d、(5.01±0.54)d、(5.85±0.64)d]均明显比对照组[(9.28±1.14)d、(3.28±0.34)d、(8.68±0.94)d、(9.28±1.44)d]短,实验组治疗后PCT、CRP指标[(0.15±0.02)ng/ml、(6.05±0.25)mg/L]均明显比参照组[(1.14±0.14)ng/ml、(15.26±1.54)mg/L]低,差异均具有统计学意义(P<0.05)。实验组不良反应发生率(4.00%)与对照组(5.33%)比较,差异无统计学意义(P>0.05)。结论小剂量糖皮质激素可在短期内有效缓解小儿支原体肺炎患者肺部啰音等症状,减轻炎症反应,且不良反应较少,值得借鉴。
Objective To analyze the effect of small dose of glucocorticoids on fever,cough and pharyngeal congestion in in adjunctive therapy for children with mycoplasma pneumonia.Methods 150 children with mycoplasma pneumonia admitted to our hospital from January 2018 to June 2019 were set as study subjets and they were control group and experimental group,75 patients in each group.Patients in the control group were treated with azithromycin,and patients in the experimental group were treated with low-dose dexamethasone sodium phosphate on the basis of the control group.The clinical efficacy,time of clinical symptoms disappearance,serum inflammatory factor index and incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the experimental group(97.33%)was significantly higher than that of the reference group(81.33%).The disappearance time of lung rales,fever,cough and pharyngeal congestion in the experimental group was[(5.06±0.62)d,(1.52±0.11)d,(5.01±0.54)d,(5.85±0.64)d)]significantly shorter than that in the control group[(9.28±1.14)d,(3.28±0.34)d,(8.68±0.94)d,(9.28±1.44)d].After the treatment,PCT and CRP indexes[(0.15±0.02)ng/ml,(6.05±0.25)mg/l]in the experimental group were significantly lower than those in the control group[(1.14±0.14)ng/ml,(15.26±1.54)mg/l],and the difference was statistically significant(P<0.05).There was no significant differences in the incidence of adverse reactions between the experimental group(4.00%)and thecontrol group(5.33%),P>0.05.Conclusions Low dose of glucocorticoid can effectively alleviate the lung rales and other symptoms in children with mycoplasma pneumonia in a short period of time,reduce the inflammatory response,and have fewer adverse reactions,which is worth learning.
作者
林瑞峰
曾彩娇
白婷
关玉云
刘杨桃
LIN Rui-feng(Department of paediatrics,people's hospital of Yangjiang City,Guangdong Province,Yangjiang,Guangdong,529500,China)
出处
《齐齐哈尔医学院学报》
2020年第12期1469-1471,共3页
Journal of Qiqihar Medical University
关键词
糖皮质激素
小儿支原体肺炎
临床疗效
炎症反应
Glucocorticoid
Mycoplasma pneumonia in children
Clinical efficacy
Inflammatory response
